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BCG-loaded chitosan microparticles: interaction with macrophages and preliminar...
Caetano, Liliana Aranha; Figueiredo, Lara; Almeida, António J.; Gonçalves, L. M. D.The aim of this study was to develop a novel BCG-loaded chitosan vaccine with high association efficiency which can afford efficient interaction with APC and elicit local and Th1-type-specific immune response after intranasal administration. Chitosan-suspended BCG and BCG-loaded chitosan-alginate microparticles were prepared by ionotropic gelation. Interaction with APC was evaluated by fluorescence microscopy u...
Development and characterization of a new plasmid delivery system based on chit...
Cadete, A.; Figueiredo, L.; Lopes, R.; Calado, Cecília; Almeida, A. J.; Gonçalves, L. M. D.Chitosan is one of the most promising polymers for drug delivery through the mucosal routes because of its polycationic, biocompatible, and biodegradable nature, and particularly due to its mucoadhesive and permeation-enhancing properties. Bile salts are known to interact with lipid membranes, increasing their permeability. The addition of bile salts to chitosan matrices may improve the delivery characteristics...