Background: Matrix metalloproteinases (MMPs) are zinc-dependent enzymes that regulate extracellular matrix degradation and remodelling. Among them, MMP-8 and MMP-9 are key mediators of inflammation, tissue remodelling, and wound healing. They have been implicated in both type 1 diabetes mellitus (T1DM) and periodontal disease (PD) [1]. The literature indicates a bidirectional association between T1DM and PD: ch...
Este artigo, cujo objeto de estudo é o livro didático, tem como principal objetivo investigar a abordagem dos textos literários existentes no ‘manual do educador´ e de que forma a sua composição textual favorece a formação do leitor. Neste sentido, procedeu-se, inicialmente, à análise de elementos paratextuais, à presença dos géneros literários, às sessões de aula voltadas para a leitura e análise do texto, rel...
Introduction: Studies have shown the worsening of migraine associated with the COVID-19 infection and the pandemic more broadly. COVID-19 vaccination has also been associated with symptomatic headache, with high frequency among migraineurs. We aimed to assess the impact of COVID-19 diagnosis and vaccine administration on migraine, during the SARS-CoV-2 pandemic. Methods: An online questionnaire was sent to migr...
Background: Severe periodontitis is considered the sixth most prevalent disease worldwide [1]. It is a chronic inflammatory condition affecting the tooth-supporting structures due to genetic, environmental, and microbial factors [2]. The host immune response partially contributes to the magnitude of the inflammatory process. Furthermore, this process involves a diversity of immunomediators that initiate and sus...
The Invisalign® system aims to ensure aesthetics and achieve positive clinical results; however, its efficacy is still debatable. Along with lower incisor intrusion and upper molar distalization, arch expansion is one of the most predictable movements that may be achieved using clear aligners. This makes the system a conceivable method for the correction of crowding and posterior dentoalveolar crossbites. The a...
Background Hope is an important resource that helps patients and families thrive during difficult times. Although several studies have highlighted the importance of hope in different contexts, its specific manifestations in the realm of advanced chronic illness need further exploration. In this study, we sought to elucidate the intricate interplay between the construct of hope and the lived experience of advanc...
Breast cancer patients struggle with psychological trauma related to body image issues linked to the required treatment. Thus, minimally invasive treatment modalities, such as microwave ablation, have been gaining attention. Additionally, personalized pre-treatment simulations that allow assessing the cosmetic outcome of the ablation can help reduce associated trauma. The aim of this paper is to propose a frame...
Background: Diagnosis delay contributes to increased tuberculosis (TB) transmission and morbimortality. TB incidence has been decreasing in Portugal, but median patient delay (PD) has risen. Symptom valorisation may determine PD by influencing help-seeking behaviour. We aimed to analyse the association between symptom valorisation and PD, while characterising individuals who disregarded their symptoms. Methods:...
Periodontitis is a chronic disease with a high overall prevalence. It involves a complex interplay between the immune-inflammatory pathways and biofilm changes, leading to periodontal attachment loss. The aims of this study were (i) to assess whether the salivary IL-1β, IL-17A, RANK-L and OPG levels have the potential to discriminate between the mild and severe periodontitis conditions; and (ii) to enable diagn...
Em Portugal, entre 2017 e 2019 verificou-se um aumento da taxa de mortalidade materna quando comparada a 20161. A hemorragia, a sepsis e a hipertensão arterial induzida pela gravidez, são apontadas como as principais causas da mortalidade materna2. Os enfermeiros que prestam cuidados às grávidas e recém-nascidos, têm a responsabilidade ética e profissional de realizarem treino contínuo, aperfeiçoando as suas c...