59 documents found, page 1 of 6

Determinants of HIV-1 Transmission Clusters and Transmitted Drug Resistance in ...

Introduction: In the EU/EEA, men who have sex with men (MSM) is a priority group for the prevention and control of HIV-1 infection. In Portugal, the 2023 HIV incidence rate was 8.2 per 100,000 inhabitants, with 876 new infections, 41.7% in MSM. We aim to characterize HIV-1 transmission clusters (TC) and transmitted drug resistance (TDR) and its sociodemographic, behavioral, clinical, and viral genomic determina...

Real-World Experience with Avacopan in ANCA-Associated Vasculitis in Portugal

Introduction: Avacopan, a selective C5a receptor inhibitor, has emerged as a potential corticosteroid-sparing treatment in ANCA-associated vasculitis (AAV). This study aims to evaluate its real-world efficacy and safety in Portuguese patients with active AAV. Methods: We conducted a multicenter retrospective analysis of 15 adult patients with newly diagnosed or relapsing AAV treated with avacopan across nine ac...

Eosinophilic granulomatosis with polyangiitis treated with Mepolizumab and Ritu...

Impact of Concordance Between Antinuclear Antibody Indirect Immunofluorescence ...

Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of systemic autoimmune rheumatic disorders in which chronic inflammation of skeletal muscle leads to muscle weakness. Many other organs, including the skin, heart, lungs, and joints, may be affected. Patients with IIM may be positive for myositis antibodies (MAs), including myositis-specific and/or associated antibodies. Although helpful for est...

Determinants of HIV-1 transmission clusters and transmitted drug resistance in ...

In the EU/EEA, men who have sex with men (MSM) is a priority group for the prevention and control of HIV-1 infection. In Portugal, the 2023 HIV incidence rate was 8.2 per 100,000 inhabitants, with 876 new infections, 41.7% in MSM. We aim to characterize HIV-1 transmission clusters (TC) and transmitted drug resistance (TDR) and its sociodemographic, behavioral, clinical, and viral genomic determinants in MSM new...

Sociodemographic, Clinical, and Behavioral Factors Associated with Sexual Trans...

Introduction: Sexually transmitted infections (STIs) continue to occur at high levels. According to the WHO, each year there are an estimated 374 million new infections with syphilis, gonorrhea, chlamydia, and trichomoniasis. STIs are associated with an increased risk of acquiring HIV infection. Migrants are reportedly highly affected by STIs. Objectives: This study aims to characterize factors associated with ...

Determinants of HIV late presentation among men who have sex with men in Portug...

Introduction: HIV late presentation (LP) remains excessive in Europe. We aimed to analyze the factors associated with late presentation in the MSM population newly diagnosed with HIV in Portugal between 2014 and 2019. Methods: We included 391 newly HIV-1 diagnosed Men who have Sex with Men (MSM), from the BESTHOPE project, in 17 countrywide Portuguese hospitals. The data included clinical and socio-behavioral q...

Viral genetics and transmission dynamics in the second wave of mpox outbreak in...

Therapeutic inertia in osteoporosis in postmenopausal women

Introduction: Osteoporosis (OP) is the most frequent metabolic bone disease, associated with fragility fractures and increased morbimortality. Despite population aging, there has been a downward trend in the implementation of anti-osteoporotic therapy. Objectives: To determine the therapeutic inertia in OP in postmenopausal women in primary health care. Verify whether age, T-score, the FRAX value, and anti-oste...

Estratégias de mitigação da obesidade infantil através de NBS: um estudo de cas...