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Monoartrite persistente do joelho como apresentação de doença de Lyme: Um desaf...
Alçada, R; Gonçalves, NP; Torres, R; Lourenço, MH; Flor de Lima, B; Guerra Pinto, F
BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective...
Lopes, CDF; Gonçalves, NP; Gomes, CP; Saraiva, MJ; Pêgo, APNeuron-targeted gene delivery is a promising strategy to treat peripheral neuropathies. Here we propose the use of polymeric nanoparticles based on thiolated trimethyl chitosan (TMCSH) to mediate targeted gene delivery to peripheral neurons upon a peripheral and minimally invasive intramuscular administration. Nanoparticles were grafted with the non-toxic carboxylic fragment of the tetanus neurotoxin (HC) to al...
Curcumin: A multi-Target disease-modifying agent for late-stage transthyretin a...
Ferreira, N; Gonçalves, NP; Saraiva, MJ; Almeida, MTransthyretin amyloidoses encompass a variety of acquired and hereditary diseases triggered by systemic extracellular accumulation of toxic transthyretinaggregates and fibrils, particularly in the peripheral nervous system. Since transthyretin amyloidoses are typically complex progressive disorders, therapeutic approaches aiming multiple molecular targets simultaneously, might improve therapy efficacy and treat...