6 documents found, page 1 of 1
Heterocyclic-based derivatives for biomedical applications as optical chemosens...
Gonçalves, Raquel Costa RaínhaOs compostos heterocíclicos são um grupo diversificado de compostos com aplicações diversas no âmbito da investigação biomédica. Os quimiossensores óticos e as sondas de bioimagem permitem a deteção sensível e em tempo real de analitos com importância biológica e a monitorização de processos biológicos. O desenvolvimento de fotossensibilizadores com propriedades fotofísicas otimizadas para terapia fotodinâmica ...
Investigating the photophysical properties and biological efficacy of BODIPY de...
Gonçalves, Raquel Costa Raínha; Pinto, Sónia Catarina Silva; Pina, João; Gomes-da-Silva, Lígia C.; Costa, Susana P. G.; Raposo, M. Manuela M.The selectivity of photosensitizers for light activation is a key advantage in photodynamic therapy (PDT), allowing for precise targeting while sparing healthy cells. BODIPY derivatives have emerged as promising PDT candidates due to their tunable photophysical properties and versatile synthesis. Herein, we explore the photophysical characterization and the in vitro photodynamic activity of BODIPY analogues mes...
Polyaromatic bis(indolyl)methane derivatives with antiprolif-erative and antipa...
Gonçalves, Raquel Costa Raínha; Peñalver, Pablo; Costa, Susana P. G.; Morales, Juan C.; Raposo, M. Manuela M.Bis(indolyl)methanes (BIM) are a class of compounds that has been recognized as an important core in the design of drugs with important pharmacological properties, such as promising anticancer and antiparasitic activity. Here, we explored the biological activity of the BIM core functionalized with different (hetero)aromatic moieties. We synthesized substituted BIM deriva-tives with triphenylamino, N,N-dimethyl-...
Synthesis and characterization of a fluorescent BODIPY derivative
Gonçalves, Raquel Costa Raínha; Costa, Susana P. G.; Raposo, M. Manuela M.Despite existing for almost a century, fluorescent dyes continue to attract the attention of scientists from an ever expanding multidisciplinary areas. Among the many diverse fluorescent molecules, 3-difluoroborodipyrromethene (BODIPY) derivatives, have become a cornerstone for innovative applications such as biological fluorescent labelling, electroluminescent devices, dye sensitized solar cells (DSSCs), photo...
N,N-Diphenylanilino-heterocyclic aldehyde-based chemosensors for UV-vis/NIR and...
Okda, Hazem Essam; El Sayed, Sameh; Ferreira, Rosa Cristina Moutinho; Gonçalves, Raquel Costa Raínha; Costa, Susana P. G.; Raposo, M. Manuela M.Herein, three N,N-diphenylanilino-heterocyclic aldehyde probes (5, 6 and 7) are synthesized, characterized and their sensing behaviour against metal cations tested. Acetonitrile solutions of the three probes show an intramolecular charge-transfer band in the 360-420 nm range due to the presence of an electron donor N,N-diphenylanilino group and an electron acceptor aldehyde moiety. Besides, all three probes are...
Synthesis and characterization of a BODIPY probe for the chromogenic detection ...
Pinto, Sónia C. S.; Gonçalves, Raquel Costa Raínha; Costa, Susana P. G.; Raposo, M. Manuela M.In recent years, the development of chromo-fluorogenic chemosensors for metal cations has attracted the attention of researchers around the world. Among transition metal cations, Cu2+ is the third most abundant essential element in the human body and plays vital roles in several physiological processes. Nevertheless, abnormal levels of this cation can cause serious health problems on humans. In fact, high conce...