3 documents found, page 1 of 1
Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling
Domingues, Neuza S.; Catarino, Steve; Cristóvão, Beatriz; Rodrigues, Lisa; Carvalho, Filomena A; Sarmento, Maria João; Zuzarte, MónicaA robust and efficient cellular response to lysosomal membrane damage prevents leakage from the lysosome lumen into the cytoplasm. This response is understood to happen through either lysosomal membrane repair or lysophagy. Here we report exocytosis as a third response mechanism to lysosomal damage, which is further potentiated when membrane repair or lysosomal degradation mechanisms are impaired. We show that ...
Do mycorrhizal fungi create below-ground links between native plants and <i>Aca...
Carvalho, Pedro; Martins, Rui; Portugal, António; Gonçalves, Teresa M.Maritime pine forests are a major ecosystem throughout the Portuguese coast and are severely affected by the invasion of Acacia longifolia. The presented study investigated the diversity of ectomycorrhizal fungi (ECM) of major plant species in these ecosystems to find possible links between Pinus pinaster, three native Cistaceae shrubs and the Acacia invasive species. We successfully identified 13 ECM fungal ta...
Candida albicans CUG mistranslation is a mechanism to create cell surface varia...
Miranda, Isabel; Silva-Dias, Ana; Rocha, Rita; Teixeira-Santos, Rita; Coelho, Carolina; Gonçalves, Teresa M.; Santos, Manuel A. S.; Pina-Vaz, CidáliaIn the human fungal pathogen Candida albicans, the CUG codon is translated 97% of the time as serine and 3% of the time as leucine, which potentially originates an array of proteins resulting from the translation of a single gene. Genes encoding cell surface proteins are enriched in CUG codons; thus, CUG mistranslation may influence the interactions of the organism with the host. To investigate this, we compare...