Cutaneous leishmaniasis are anthropozoonoses caused by protozoa of the Leishmania genus. Leishmania braziliensis is most popular specie in Brazil. Plectranthus amboinicus, popularly known in Brazil as “malvarisco”, belongs to the family Lamiaceae. It has a great economic importance because of its widely medicinal use. In this work, the in vitro and in vivo effect of the ethyl acetate extracted of Plectranthus a...
Antimicrobials benefited the history of medicine by revolutionizing the treatment of infectious diseases. However, its consequent and continuous use has led to the emergence of microorganisms which once were considered safe, but have become feared as potentially lethal pathogens (Bowler et al., 2012). Staphylococcus aureus infections are highlighted for being a major cause of systemic infections, and for being ...
Recently, there has been a significant increase in invasive fungal infections, the treatment of which is limited to a quite small number of antifungal drugs. Natural products represent an important source of antifungal agents, mainly because of their natural coexistence with fungi present in each biome. Derivatives or semi-synthetic products can be used to optimize the pharmacological profile of natural product...
This work describes the first study about the antimicrobial activity and mechanisms of action of the subinihibitory and inhibitory concentrations essential oil from leaves of Plectranthus amboinicus against standard strain of Klebsiella pneumoniae and multresistant clinical isolates of the bacterium. The minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC), the rate of killing and...
We evaluated the antimicrobial activity and some mechanisms used by subinhibitory and inhibitory concentrations of the essential oil, obtained from leaves of Plectranthus amboinicus , against a standard strain of Klebsiella pneumoniae and 5 multiresistant clinical isolates of the bacteria. The minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC), the rate of kill and the pH sensit...
Objectives: Leprosy household contacts represent a group at high risk of developing the disease. The aim of this study was to detect Mycobacterium leprae subclinical infection in this group through serological and molecular parameters. Methods: Serum anti-PGL1 IgG/IgM and salivary anti-PGL1 IgA/IgM was investigated using an ELISA, and nasal carriage of M. leprae DNA was detected by PCR, in leprosy household con...