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Butylone enantioseparation and ecotoxicity evaluation on Daphnia magna
Carvalho, A. R.; Morão, A. M.; Gonçalves, V. M. F.; Tiritan, M. E.; Lado, A. R.; Carrola, J. S.; Amorim, M. M.; Ribeiro, C.Background: The synthetic drug butylone (2-methylamino-1-(3,4-methylenedioxyphenyl)butan-1-one, BTL) is a chiral cathinone consumed in the form of racemate [1]. After consumption, BTL is metabolized and excreted along with its metabolites, and its residues are carried by sewerage systems to wastewater treatment plants (WWTPs) [2]. Both human metabolism and biodegradation in WWTPs may be enantioselective causing...
Tea and herbal infusions consumption in Portugal: consumer behaviors
Sousa, A. C.; Ribeiro, C.; Gonçalves, V. M. F.; Pádua, I.; Leal, S.Background: Tea and herbal infusions (THIs) consumption is recognized for its beneficial effects, which are attributed to the antioxidant properties of phenolic compounds [1–3].The wide diversity of THIs available in market and the absence or failure in quality control can expose the population to health risks [3]. Moreover, uncontrolled consumption may cause toxicity or lack of the expected benefits. Therefore...
Enantiomeric profiling and drug consumption estimation
Langa, I.; Ribeiro, A. R. L.; Ratola, N.; Gonçalves, V. M. F.; Tiritan, M. E.; Ribeiro, C.Background: Recent trends in new psychoactive substances (NPS) abuse have raised a serious public health issue that affects all communities. NPS comprise a wide range of substances, such as synthetic cathinones, synthetic cannabinoids, opioids, and benzodiazepines [1, 2]. These substances end up in the environment as excretion products or by direct disposal [3]. Wastewater-based epidemiology (WBE) combined with...
Erythrocyte-derived liposomes for the treatment of inflammatory diseases
Olival, Ana Sofia Martins; Vieira, Sara Filipa Fontoura; Gonçalves, V. M. F.; Cunha, C.; Tiritan, M. E.; Carvalho, A.; Reis, R. L.Effective and safe therapies to counteract persistent inflammation are necessary. We developed erythrocyte-derived liposomes (EDLs) with intrinsic anti-inflammatory activity. The EDLs were prepared using lipids extracted from erythrocyte membranes, which are rich in omega-3 fatty acids with several health benefits. Diclofenac, a widely used anti-inflammatory drug, was incorporated into EDLs in relevant therapeu...
Sardine roe as a source of lipids to produce liposomes
Guedes, M.; Costa-Pinto, A. R.; Gonçalves, V. M. F.; Moreira-Silva, J.; Tiritan, M. E.; Reis, R. L.; Ferreira, H.; Neves, N. M.Sea-derived materials have promising applications in the medical, pharmaceutical, and biotechnological fields. Fish roe, for example, is a highly nutritional product, presenting diverse beneficial effects on human health. Therefore, this work explored extracts of sardine (Sardina pilchardus) roe, due to the well-known health benefits of this fish, to produce novel and promising delivery systems. After morpholog...