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Can continuous glucose monitoring predict cystic fibrosis-related diabetes and ...
Zorron,Mariana; Marson,Fernando Augusto Lima; Morcillo,André Moreno; Gonçalves,Aline Cristina; El Beck,Mayra de Souza; Ribeiro,José DirceuABSTRACT Objective: To determine whether abnormal continuous glucose monitoring (CGM) readings (hypoglycemia/hyperglycemia) can predict the onset of cystic fibrosis-related diabetes (CFRD) and/or clinical impairment (decline in BMI and/or FEV1) in pediatric patients with cystic fibrosis (CF). Methods: This was a longitudinal prospective cohort study involving CF patients without diabetes at baseline. The mean f...
Chloride and sodium ion concentrations in saliva and sweat as a method to diagn...
Gonçalves,Aline Cristina; Marson,Fernando Augusto Lima; Mendonça,Regina Maria Holanda; Bertuzzo,Carmen Sílvia; Paschoal,Ilma AparecidaAbstract Objective: Cystic fibrosis diagnosis is dependent on the chloride ion concentration in the sweat test (≥ 60 mEq/mL - recognized as the gold standard indicator for cystic fibrosis diagnosis). Moreover, the salivary glands express the CFTR protein in the same manner as sweat glands. Given this context, the objective was to verify the correlation of saliva chloride concentration and sweat chloride concent...
Insulin therapy in patients with cystic fibrosis in the pre-diabetes stage: a s...
Pu,Mariana Zorrón Mei Hsia; Christensen-Adad,Flávia Corrêa; Gonçalves,Aline Cristina; Minicucci,Walter José; Ribeiro,José DirceuAbstract Objective: To elucidate whether insulin is effective or not in patients with cystic fibrosis before the diabetes mellitus phase. Data source: The study was performed according to the Prisma method between August and September 2014, using the PubMed, Embase, Lilacs and SciELO databases. Prospective studies published in English, Portuguese and Spanish from 2002 to 2014, evaluating the effect of insulin o...