27 documents found, page 1 of 3

Potential use of renin-angiotensin-aldosterone system inhibitors to reduce COVI...

SARS-CoV-2 infection and its clinical manifestations (COVID-19) quickly evolved to a pandemic and a global public health emergency. The limited effectivity of available treatments aimed at reducing virus replication and the lessons learned from other coronavirus infections (SARS-CoV-1 or NL63) that share the internalization process of SARS-CoV-2, led us to revisit the COVID-19 pathogenesis and potential treatme...

Evidence of Air and Surface Contamination with SARS-CoV-2 in a Major Hospital i...

As the third wave of the COVID-19 pandemic hit Portugal, it forced the country to reintroduce lockdown measures due to hospitals reaching their full capacities. Under these circumstances, environmental contamination by SARS-CoV-2 in different areas of one of Portugal's major Hospitals was assessed between 21 January and 11 February 2021. Air samples (n = 44) were collected from eleven different areas of the Hos...

Skin temperature response to thermal stimulus in patients with hyperhidrosis: A...

ABS TRACT Primary hyperhidrosis (HH), the excessive sweating exceeding physiological demand, has been associated to a complex dysfunction of the autonomic nervous system which may explain the disfunction in sweating but may also cause unrevealed alterations in skin blood flow regulation. In fact, HH patients present a sympathetic over-function with less reflex bradycardia in response to the Valsalva maneuver an...

O Pólo do Mar da Universidade do Porto. Criar as bases para uma nova economia d...

OPPOSITE MODULATION OF ASTROGLIAL PROLIFERATION BY ADENOSINE 5 '-O-(2-THIO)-DIP...

The contribution of P2Y(12,13) receptors to astroglial proliferation was investigated by testing the effects of two agonists with high affinity for these receptors, adenosine 5'-O-(2-thio)-diphosphate (ADP beta S) and 2-methylthioadenosine-5'-diphosphate (2-MeSADP), in the incorporation of [H-3]-thymidine. The effect of ATP, an endogenous inducer of astroglial proliferation, was also investigated. ADP beta S an...

Inhibition of human immunodeficiency virus type 1 replication with artificial t...

The human immunodeficiency virus type 1 (HIV-1) primer-binding site (PBS) is a highly conserved region in the HIV genome and represents an attractive target for the development of new anti-HIV therapies. In this study, we designed four artificial zinc fin

Interaction between adenosine A(2B)-receptors and alpha(2)-adrenoceptors on the...

In the prostatic portion of rat vas deferens, activation of adenosine A(2B)-receptors, beta(2)-adrenoceptors, adenylyl cyclase or protein kinase A caused a facilitation of noradrenaline release. Blockade of alpha(2)-adrenoceptors with yohimbine (1 mu M) attenuated the facilitation mediated by adenosine A(2B)-receptors and by direct activation of adenylyl cyclase with forskolin but not that mediated by beta(2)-a...

Intrabodies targeting the Kaposi sarcoma-associated herpesvirus latency antigen...

Kaposi sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen-1 (LANA1) is essential for the maintenance and segregation of viral episomes in KSHV latently infected B cells. We report development of intracellular, rabbit-derived antibodi

Cell type-specific targeting with Sindbis pseudotyped lentiviral vectors displa...

Lentiviral vectors are among the most efficient tools for gene delivery into mammalian cells. A major goal of lentiviral gene delivery systems is to develop vectors that can efficiently target specific cell types. In the present work, we attempt to genera

Functional analysis of vif protein shows less restriction of human immunodefici...

Viral infectivity factor (Vif) is one of the human immunodeficiency virus (HIV) accessory proteins and is conserved in the primate lentivirus group. This protein is essential for viral replication in vivo and for productive infection of nonpermissive cell