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Characterization of TGF-ß expression and signaling profile in the adipose tissu...

Sousa-Pinto, Bernardo; Goncalves, Laura; Rodrigues, Adriana R.; Tomada, Inês; Almeida, Henrique; D Neves; Gouveia, Alexandra

Transforming growth factor beta (TGF-ß) plays an important role in the pathogenesis of obesity, influencing the release of inflammation mediators and promoting remodeling and collagen deposition in the adipose tissue (AT). In this context, this work aims to elucidate whether TGF-ß and Smad-dependent or Smad-independent signaling pathways contribute to regional differentiation of AT in high-fat diet (HFD) and en...

Date: 2016 | Origin: Repositório Aberto da Universidade do Porto

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