17 documents found, page 1 of 2
In silico, NMR and pharmacological evaluation of an hydroxyoxindole cholinester...
Carreiro, Elisabete; Burke, Anthony; Bacalhau, Patricia; Martins, M. Rosário; Fernandes, Luis; Caldeira, A. Teresa; Candeias, Fátima; Guedes, RitaFrom a screening study of various potential inhibitors for cholinesterases (ChEs), compound (rac)-1 (4-((3-hydroxy-2-oxo-3-phenylindolin-1-yl) methyl) piperidin-1-ium chloride) showed an IC50 of 18 μM for butyrylcholinesterase (BuChE). Herein we present a toxicological and pharmacological evaluation of (rac)-1 to determine its potential for use as an alternative ChE inhibitor for the treatment of Alzheimer’s di...
Caracterização química e potencial antioxidante de óleos essenciais de Lavandul...
Arantes, Sílvia Macedo; Piçarra, Andreia; Candeias, Fátima; Pereira, Marízia; Raposo, Mauro; Gomes, Carlos Pinto; Caldeira, A. TeresaO Alentejo é uma região extremamente rica em plantas aromáticas e medicinais (PAMs) autóctones, muitas das quais preservadas pelas populações locais, com aplicação na medicina tradicional, bem como utilizadas como condimentos na Dieta Mediterrânea. A família Lamiaceae contém importantes PAMs, com óleos essenciais (OEs) ricos em terpenos, utilizados na medicina tradicional e moderna e nas indústrias alimentar e ...
Avaliação do conteúdo fenólico e potencial antioxidante de extratos aquosos de ...
Piçarra, Andreia; Gomes, Laura; Arantes, Sílvia M.; Candeias, Fátima; Caldeira, A. Teresa; Martins, M. RosárioOs extratos de plantas, são ricos em polifenóis que possuem um importante potencial antioxidante devido à sua capacidade de captação de radicais livres ou de proteção de oxidação dos substratos lipídicos, desempenhando um papel importante na prevenção de patologias relacionadas ao stress oxidativo, como doenças neurodegenerativas e cardiovasculares. O Alentejo é rico em plantas aromáticas autóctones, muitas uti...
Toxicological and pharmacological properties of essential oils of Calamintha ne...
Macedo Arantes, Sílvia; Piçarra, Andreia; Guerreiro, Marisa; Salvador, Cátia; Candeias, Fátima; Caldeira, A.Teresa; Martins, M. RosárioThree autochthonous flavouring herbs from Alentejo (Portugal), Calamintha nepeta (syn. Clinopodium nepeta), Origanun virens and Thymus mastichina, were selected to evaluate toxicological, antioxidant, antiproliferative and antimicrobial potential of their essential oils (EOs). C. nepeta and T. mastichina EOs showed a high content of oxygenated monoterpenes (86–91%) while O. virens had similar content of oxygena...
Essential oils of Calamintha nepeta, Origanum vulgare and Thymus mastichina of ...
Arantes, Sílvia M.; Piçarra, Andreia; Guerreiro, Marisa; Salvador, Cátia; Candeias, Fátima; Caldeira, A.Teresa; Martins, M.RosárioAlentejo, in the south of Portugal, is rich in endemic aromatic plants, that are used as condiments and food additives by the local population. The aim of this study was to evaluate the antioxidant, antimicrobial and antiproliferative activities of EOs of autochthones Calamintha nepeta (L.) Savi (syn. Clinopodium nepeta (L.) Kuntze), Origanum vulgare L., and Thymus mastichina L. EOs were extracted from the aeri...
In silico, NMR and pharmacological evaluation of an hydroxyoxindole cholinester...
Bacalhau, Patrícia; Fernandes, Luís; Martins, M. Rosário; Candeias, Fátima; Carreiro, Elisabete P.; Caldeira, A.Teresa; Guedes, Rita C.From a screening study of various potential inhibitors for cholinesterases (ChEs), compound (rac)-1 (4-((3-hydroxy-2-oxo-3-phenylindolin-1-yl) methyl) piperidin-1-ium chloride) showed an IC50 of 18 μM for butyrylcholinesterase (BuChE). Herein we present a toxicological and pharmacological evaluation of (rac)-1 to determine its potential for use as an alternative ChE inhibitor for the treatment of Alzheimer’s di...
Aqueous extracts of Origanum vulgare and Thymus spp. from Alentejo: Anti-inflam...
Piçarra, Andreia; Arantes, Sílvia M.; Candeias, Fátima; Gomes, Carlos Pinto; Caldeira, A. Teresa; Martins, M. RosárioMediterranean diet, intangible cultural heritage of Humanity, is a fundamental pillar for sustainable development of populations. Alentejo is rich in indigenous aromatic plants in Montado cork oak forests, many of them used in traditional Medicine as well as food flavours in Mediterranean diet. Moreover, Medicinal, aromatic and flavouring plants (MAPs) and their extracts are rich in phenolic compounds and play ...
Antioxidant activity and cholinesterase inhibition studies of four flavouring h...
Arantes, Silvia; Piçarra, Andreia; Candeias, Fátima; Teixeira, Dora; Caldeira, A. Teresa; Martins, M. RosárioEssential oils (EOs) and aqueous extracts of aerial parts of four aromatic species, Calamintha nepeta, Foeniculum vulgare, Mentha spicata and Thymus mastichina, from southwest of Portugal were characterised chemically and analysed in order to evaluate their antioxidant potential and cholinesterase inhibitory activities. The main components of EOs were oxygenated monoterpenes, and aqueous extracts were rich in p...
Pharmacological and Toxicological Studies of Essential Oil of Lavandula stoecha...
Arantes, Sílvia; Candeias, Fátima; Lopes, Orlando; Lima, Mónica; Pereira, Marízia; Tinoco, Teresa; Cruz-Morais, Júlio; Martins, M. RosárioThe present study was carried out to evaluate the chemical and pharmacological properties of essential oil (EO) of Lavandula stoechas L. subsp. luisieri that is a spontaneous shrub widespread in Alentejo (Portugal). Oxygenated monoterpenes, as 1,8-cineole, lavandulol and necrodane derivatives are the main components of essential oil. It revealed important antioxidant activity with high ability to inhibit the li...
Biomarker evaluation and toxicological study of essential oils of Foeniculum vu...
Piçarra, Andreia; Arantes, Silvia; Candeias, Fátima; Lopes, Orlando; Lima, Mónica; Tinoco, Teresa; Martins, RosárioThe aim of this study was to evaluate the toxicological properties of EOs of F. vulgare and C. nepeta, widespread in Mediterranean agrosilvopastoral systems and often used as food condiments in Alentejo. EOs were obtained from aerial part of plants by hydrodistillation and chemical composition was evaluated by GC-FID. Toxicity of essential oils was evaluated by the estimation of LC50 in brine shrimp and LD50 in...