The CRISPR/Cas9 system has emerged as a promising platform for gene editing; however, the lack of an efficient and safe delivery system to introduce it into cells continues to hinder clinical translation. Here, we report a rationally designed gene-editing nanoparticle (NP) formulation for brain applications: an sgRNA:Cas9 ribonucleoprotein complex is immobilized on the NP surface by oligonucleotides that are co...
En el siguiente artículo se aborda la importancia que tiene el Sistema Métrico Decimal (SMD) en la enseñanza de las matemáticas, y en su aplicación en el resto de las ciencias. El propósito principal es el de estudiar las Redes Cognitivas en el aprendizaje del SMD. La muestra está formada por alumnos del primer curso de Educación Secundaria Obligatoria en el Sistema Educativo español. Para este estudio se emple...
This paper analyzes various tactics promoted by the evangelizers of the Viceroyalty of Peru tending to create common narrative or ritual spaces able to integrate the indigenous population into Christian practice because of their own expectations and experiences by the symbiosis of characters of the gospel history with American events or the superimposition of Christian marks on Andean objects of worship. Finall...
Sem resumo.