4 documents found, page 1 of 1
Effect of co-administration of BRL-37344 and tadalafil on reduction of overacti...
Carvalho, Marcos Fiuza de; Pamplona, Thuliermes Lopes; Barreira, Márcio Alencar; Fechine, Francisco Vagnaldo Jamacuru; Gonzaga-Silva, Lúcio FlávioPurpose: To evaluate the impact of the combination of BRL 37344 and tadalafil (TDF) on the reduction of overactive bladder (OB) symptoms. Methods: Thirty mice were randomized into 5 groups (G) of 6 animals each. L-NAME was used to induce DO. G1: Control; G2: L-NAME; G3: L-NAME + TDF; G4: L-NAME + BRL 37344; G5: L-NAME + TDF + BRL 37344. After 30 days of treatment, the animals were submitted to cystometry to eva...
Impact of testicular sperm extraction and testicular sperm aspiration on gonada...
Barroso, Leocácio Venícius Sousa; Reges, Ricardo; Cerqueira, João Batista Gadelha; Miranda, Eduardo P.; Alcantara, Rafael Jorge Alves dePurpose: To assess the impact of sperm retrieval on the gonadal function of rats with impaired spermatogenesis by comparing testicular sperm extraction (TESE) to aspiration (TESA). The efficacy of these procedures to sperm obtainment was also compared. Materials and Methods: A pilot study showed impaired spermatogenesis, but normal testosterone (T) production after a bilateral orchidopexy applied to 26 rats, wh...
Effects of chronic administration of tamsulosin and tadalafil, alone or in comb...
Regadas, Rommel Prata; Reges, Ricardo; Cerqueira, João Batista Gadelha; Sucupira, Daniel Gabrielle; Jamacaru, Francisco Vagnaldo FechinePurpose: The aim of this study was to define if tadalafil causes detrusor muscle impairment and to observe the effect of combination of tadalafil with tamsulosin on the lower urinary tract of rats with bladder outlet obstruction (BOO) induced by chronic nitric oxide deficiency. Materials and Methods: Thirty-one male rats were randomized to following groups: 1 - control; 2 - L-Nitroarginine methyl ester (L-NAME)...
Phosphodiesterase inhibitors for treatment of voiding dysfunction : an overview...
Reges, Ricardo; Regadas, Rommel Prata; Cerqueira, João Batista Gadelha; Gonzaga-Silva, Lúcio FlávioRecently, the focus of the origin of lower urinary tract symptoms (LUTS) has change from the prostate to the bladder. Regardless of the underlying mechanism associated with the origin of LUTS, alpha-blockers continue to be the most common medicine prescribed to treat LUTS due to benign prostatic obstruction (BPO). The newest class of drug introduced to treat LUTS/BPO is phosphodiesterase inhibitors (PDEi) and t...