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Effect of co-administration of BRL-37344 and tadalafil on reduction of overacti...
Carvalho,Marcos Fiuza de; Pamplona,Thuliermes Lopes; Barreira,Márcio Alencar; Fechine,Francisco Vagnaldo Jacuru; Gonzaga-Silva,Lúcio FlávioAbstract Purpose: To evaluate the impact of the combination of BRL 37344 and tadalafil (TDF) on the reduction of overactive bladder (OB) symptoms. Methods: Thirty mice were randomized into 5 groups (G) of 6 animals each. L-NAME was used to induce DO. G1: Control; G2: L-NAME; G3: L-NAME + TDF; G4: L-NAME + BRL 37344; G5: L-NAME + TDF + BRL 37344. After 30 days of treatment, the animals were submitted to cystomet...
Impact of testicular sperm extraction and testicular sperm aspiration on gonada...
Barroso,Leocácio Venícius Sousa; Reges,Ricardo; Cerqueira,João Batista Gadelha; Miranda,Eduardo P.; Alcantara,Rafael Jorge Alves deABSTRACT Purpose To assess the impact of sperm retrieval on the gonadal function of rats with impaired spermatogenesis by comparing testicular sperm extraction (TESE) to aspiration (TESA). The efficacy of these procedures to sperm obtainment was also compared. Materials and Methods A pilot study showed impaired spermatogenesis, but normal testosterone (T) production after a bilateral orchidopexy applied to 26 r...
Effects of chronic administration of tamsulosin and tadalafil, alone or in comb...
Regadas,Rommel Prata; Reges,Ricardo; Cerqueira,João Batista Gadelha; Sucupira,Daniel Gabrielle; Jamacaru,Francisco Vagnaldo F.; Moraes,Manoel Odorico dePurpose The aim of this study was to define if tadalafil causes detrusor muscle impairment and to observe the effect of combination of tadalafil with tamsulosin on the lower urinary tract of rats with bladder outlet obstruction (BOO) induced by chronic nitric oxide deficiency. Materials and Methods Thirty-one male rats were randomized to following groups: 1 - control; 2 - L-Nitroarginine methyl ester (L-NAME); ...
Identification of mechanisms involved in the relaxation of rabbit cavernous smo...
Cerqueira,João Batista Gadelha de; Gonzaga-Silva,Lúcio Flávio; Silva,Francisco Ordelei Nascimento da; Cerqueira,João Victor Medeiros dePURPOSE: The aim of this study was to evaluate the relaxation in vitro of cavernous smooth muscle induced by a new NO donor of the complex nitrosil-ruthenium, named trans-[Ru(NH3)4(caffeine)(NO)]C13 (Rut-Caf) and sodium nitroprusside (SNP). MATERIALS AND METHODS: The tissues, immersed in isolated bath systems, were pre-contracted with phenilephrine (PE) (1 µM) and then concentration-response curves (10-12 - 10-...
Locally advanced penile carcinoma: classic emasculation or testis-sparing surgery?
Gonzaga-Silva,Lúcio Flávio; Lima,George R. M.; Tavares,José M.; Pinheiro,Vladmir O.; Magalhães,George A.; Tomas,Manoel E.; Nogueira,Cleto D.Purpose The study evaluates the clinical and pathological findings of 16 patients with locally advanced penile carcinoma (PC) submitted to emasculation, and discusses questions related to the usefulness of bilateral orchiectomy. Materials and Methods Between 1999 and 2010, 172 patients with PC were treated. Sixteen (9%) underwent emasculation. Data were retrieved from the institution's database including age, e...