2 documents found, page 1 of 1
Tumor-Infiltrating T Cells in Skin Basal Cell Carcinomas and Squamous Cell Carc...
Cunha, D; Neves, M; Silva, D; Silvestre, AR; Nunes, PB; Arrobas, F; Ribot, JC; Ferreira, F; Moita, LF; Soares-de-Almeida, L; Silva, JM; Filipe, PBasal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) are high-incidence, non-melanoma skin cancers (NMSCs). The success of immune-targeted therapies in advanced NMSCs led us to anticipate that NMSCs harbored significant populations of tumor-infiltrating lymphocytes with potential anti-tumor activity. The main aim of this study was to characterize T cells infiltrating NMSCs. Flow cytometry and immuno...
Immunomodulatory Effects and Protection in Sepsis by the Antibiotic Moxifloxacin
Velho, TR; Raquel, H; Figueiredo, N; Neves-Costa, A; Pedroso, D; Santos, I; Willmann, K; Moita, LFSepsis is a leading cause of death in Intensive Care Units. Despite its prevalence, sepsis remains insufficiently understood, with no substantial qualitative improvements in its treatment in the past decades. Immunomodulatory agents may hold promise, given the significance of TNF-α and IL-1β as sepsis mediators. This study examines the immunomodulatory effects of moxifloxacin, a fluoroquinolone utilized in clin...