3 documents found, page 1 of 1
Characterizing the molecular and physiological changes associated with colorect...
Silva-Reis, R; Faustino-Rocha, Ana I; Castro-Ribeiro, C; Gonçalves, M; Ferreira, T; Pires, MJ; Iglesias- Aguierre, CE; Cortés-Martín, A; Selma, MVCharacterizing the molecular and physiological changes associated with colorectal cancer in wistar rats
An integrative approach to characterize the early phases of dimethylhydrazine-i...
Silva-Reis, Carla; Castro-Ribeiro, C; Gonçalves, M; Ferreira, T; Pires, MJ; Iglesias-Aguirre, CE; Cortés-Martín, A; Selma, MV; Espín, JCThis study aimed to characterize an animal model of colorectal cancer (CRC) in the early stages of disease development. Twenty-nine male Wistar rats were divided into two control groups (CTRL1 and CTRL2), receiving EDTA–saline injections and two induced groups (CRC1 and CRC2), receiving 1,2-dimethylhydrazine (DMH) injections for seven consecutive weeks. CRC1 and CTRL1 were euthanized at the 11th week, while CRC...
Pre-neoplastic lesions associated with liver and colon responses to 1,2-dimethy...
Silva-Reis, C; Faustino-Rocha, AI; Castro-Ribeiro, C; Gonçalves, M; Ferreira, T; Gama, A; Ferreira, F; Oliveira, PABackground: Oestrogen (ER) and androgen (AR) receptors play an important role in normal prostate development and are also implied in prostate cancer (PCa) development. Several studies suggested that physical activity may decrease the risk of PCa development and also changes sexual hormones and their receptors. This study aimed to evaluate the effects of physical exercise on ERα and AR expression in a rat model ...