4 documents found, page 1 of 1
The Potential of Metabolomics in the Diagnosis of Thyroid Cancer
Coelho, M; Raposo, L; Goodfellow, BJ; Atzori, L; Jones, J; Manadas, BThyroid cancer is the most common endocrine system malignancy. However, there is still a lack of reliable and specific markers for the detection and staging of this disease. Fine needle aspiration biopsy is the current gold standard for diagnosis of thyroid cancer, but drawbacks to this technique include indeterminate results or an inability to discriminate different carcinomas, thereby requiring additional sur...
NMR metabolomics of human lung tumours reveals distinct metabolic signatures fo...
Rocha, CM; Barros, AS; Goodfellow, BJ; Carreira, IM; Gomes, AA; Sousa, V; Bernardo, J; Carvalho, L; Gil, AM; Duarte, IFLung tumour subtyping, particularly the distinction between adenocarcinoma (AdC) and squamous cell carcinoma (SqCC), is a critical diagnostic requirement. In this work, the metabolic signatures of lung carcinomas were investigated through (1)H NMR metabolomics, with a view to provide additional criteria for improved diagnosis and treatment planning. High Resolution Magic Angle Spinning Nuclear Magnetic Resonanc...
Detection of muconic acid type structures in oxidised lignins using 2D NMR spec...
Evtuguin, DV; Rocha, G; Goodfellow, BJThe identification of muconic acid type structures (MATS) in oxidised lignins employing 2D NMR spectroscopy was carried out. The primary database for MATS detection by single bond (1)H-(13)C (HSQC) and long-range (1)H-(1)H and (1)H-(13)C correlation (COSY and HMBC) NMR experiments was obtained with a series of model compounds: cis, cisand trans, trans-muconic acids and their methylated analogues and MATS derive...
Metal complexes of dipyridine hexaaza macrocycles. Structural differences betwe...
Branco, L; Costa, J; Delgado, R; Drew, MGB; Felix, V; Goodfellow, BJThe hexaaza macrocycles 3,6,14,17,23,24-hexaazatricyclo[ 17.3.1.1(8,12)]tetracosa-1(23), 8,10,12(24), 19,21-hexaene ([18]py(2)N(4)) and 3,7,15,19,25,26-hexaazatricyclo[19.3.1.1(9,13)]hexacosa-1(25), 9,11,13(26), 21,23-hexaene ([20]py(2)N(4)) were synthesised. The protonation constants of both compounds and the stability constants of their complexes with a wide range of metal ions (Mn2+, Ni2+, Cu2+, Zn2+, Cd2+, ...