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Reliability and validity of the Portuguese version of the Generalized Anxiety D...

Sousa, Tiago V.; Viveiros, Vânia; Chai, Maria V.; Vicente, Filipe L; Jesus, Gustavo; Carnot, Maria J.; Gordo, Ana C.; Ferreira, Pedro Lopes

Background: Generalized anxiety disorder has a strong impact on health-related quality of life. For this reason, it seems relevant to develop strategies allowing early diagnoses in order to promote appropriate treatments. The objective of this study was to culturally adapt and validate the GAD-7 for the Portuguese patients with generalized anxiety disorder. Methods: For the cultural adaptation of the Portuguese...

Date: 2015   |   Origin: Estudo Geral - Universidade de Coimbra
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Unconjugated bilirubin activates and damages microglia

Gordo, Ana C.; Falcao, Ana S.; Fernandes, Adelaide; Brito, Maria A.; Silva, Rui F. M.; Brites, Dora

Microglia are the resident immune cells of the brain and are the principal source of cytokines produced during central nervous system inflammation. We have previously shown that increased levels of unconjugated bilirubin (UCB), which can be detrimental to

Date: 2006   |   Origin: Repositório da Universidade de Lisboa
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