4 documents found, page 1 of 1
Bioprospecting Anticancer Compounds from the Marine-Derived Actinobacteria Acti...
Silva,Amaro E. T.; Guimarães,Larissa A.; Ferreira,Elthon G.; Torres,Maria da Conceição M.; Silva,Alison B. da; Branco,Paola C.The actinomycete strain BRA 177 was recovered from sediment samples collected at the St. Peter and St. Paul Archipelago, Brazil. This work accessed the ability of this strain, identified as Actinomadura sp., to produce bioactive metabolites by exploring the genome and characterizing chemistry and cytotoxicity of isolated compounds. From the crude ethyl acetate extract, the pigments nonylprodigiosin, cyclononylp...
Perezone, from the gorgonian Pseudopterogorgia rigida, induces oxidative stress...
Abreu,Paula A.; Wilke,Diego V.; Araujo,Ana J.; Marinho-Filho,José Delano B.; Ferreira,Elthon G.; Ribeiro,Carlos Margo R.; Pinheiro,Leandro S.Abstract Four bisabolanes 1–4, including perezone (1) and triacetyl perezone (2), were isolated through a bioassay-guided fractionation of the extract obtained from the Caribbean gorgonian coral Pseudopterogorgia rigida collected during an expedition cruise to the Bahamas. All isolated compounds showed to be cytotoxic toward panel of four human tumor cell lines, as quantified by the MTT assay after 72 h incubat...
Antibacterial, antifungal and cytotoxic activities exhibited by endophytic fung...
Felício,Rafael de; Pavão,Gabriel B.; Oliveira,Ana Lígia L. de; Erbert,Cíntia; Conti,Raphael; Pupo,Monica T.; Furtado,Niege A.J.C.; Ferreira,Elthon G.Abstract Marine environment is one of the most important sources regarding natural products research. Besides, marine microorganisms have been denominated as a talented natural source for discovery of new leads. Although the association of macroalgae and fungi has been described regarding ecological issues, there is a lack of studies about marine seaweed endophytic fungi. In this context, the goal of this study...
New Alkaloids from Margaritopsis carrascoana (Rubiaceae)
Nascimento,Raimundo R. G.; Pimenta,Antônia T. A.; Lima Neto,Pedro de; C. Junior,José R.; Costa-Lotufo,Letícia V.; Ferreira,Elthon G.Two new alkaloids containing Nb-methyl-triptamine units linked to bis-quinoline moieties, N-8”-formyl-calycosidine and N-8”-methyl-N-1’-demethyl-iso-calycosidine, were isolated from the aerial part of Margaritopsis carrascoana, along with known calycosidine and hodgkinsine. The cytotoxicity of the isolated alkaloids has been evaluated against cancer cell lines. The first two compounds showed only weak activity ...