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Relationship between Electrochemical Parameters, Cytotoxicity Data against Canc...
Paiva,Yen G. de; Silva,Thaissa L.; Xavier,André F. A.; Cardoso,Mariana F. C.; Silva,Fernando C. da; Silva,Maria F. S.; Pinheiro,Daniel P.Electrochemical methods are powerful in the characterization and design of redox-modulating agents. We, herein, report the electrochemical investigation, in aprotic medium, of eleven synthetic 3-thio-substituted-nor-beta-lapachones, along with the determination of cytotoxic activity and correspondent selectivity index, against several cancer cell lines and one normal cell. Four of the quinones are novel compoun...
Improved NADH Electroanalysis on Nickel(II) Phthalocyanine Tetrasulfonic Acid/C...
Ribeiro,Izabela Aparecida L.; Yotsumoto-Neto,Sakae; Santos,Wallans T. P. dos; Fernandes,Ridvan N.; Goulart,Marilia O. F.; Damos,Flavio S.This work describes the electrochemical performance of a novel composite based on nickel tetrasulfonated phthalocyanine (NiTsPc), deoxyribonucleic acid from calf thymus (CT-DNA) and reduced graphene oxide (rGO) for the electroanalysis of reduced β-nicotinamide adenine dinucleotide (NADH), through electrocatalytic oxidation. The modified electrode was denoted as CT-DNA/NiTsPc/rGO. Fourier transform infrared and ...
Cytotoxic, trypanocidal activities and physicochemical parameters of nor-²-lapa...
Silva Júnior,Eufrânio N. da; Moura,Maria Aline B. F. de; Pinto,Antonio V.; Pinto,Maria do Carmo F. R.; Souza,Maria Cecília B. V. de; Araújo,Ana J.The cytotoxicities of five nor-²-lapachone-based 1,2,3-triazoles and the precursor azidonaphthoquinone were assayed against six neoplasic cancer cell lines: SF-295 (central nervous system), HCT-8 (colon), MDAMB-435 (melanoma), HL-60 (leukaemia), PC-3 (prostate) and B-16 (murine melanoma). IC50 values ranging from 0.43 to 9.48 µM were obtained. 3-(4-(1-hydroxycyclohexyl)-1H-1,2,3-triazol-1yl)-2,2-dimethylnaphtho...
Adsorption studies of trifluralin on chitosan and its voltammetric determinatio...
Melo,Acácia Maria dos Santos; Valentim,Iara Barros; Goulart,Marilia O. F.; Abreu,Fabiane Caxico deThe studies about adsorption of the herbicide trifluralin (TRF), on chitosan, were carried out by batch methods using temperatures from 298 up to 313 K. The adsorption results were well fitted to Langmuir adsorption model. The obtained enthalpic value of -10.2 ± 0.8 kJ mol-1 confirms that the TRF-chitosan interaction is exothermic and that the adsorption process is relative to electrostatic interaction between ...