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Prostate cancer progression

Sousa, RD; Zagalo, Daniela Mariana; Gouveia, Miguel; Gomes, Luís Antunes; Santos Dias, José; Mansinho, André; Santos, Susana; Mariano, José

AIMS/BACKGROUND: Prostate cancer is the most common malignancy in men and a leading cause of cancer-related death. Progression from non-metastatic castration-resistant prostate cancer (nmCRPC) to metastatic CRPC (mCRPC) significantly worsens health-related quality of life (HRQoL), increases mortality, and raises healthcare costs. This study assessed the impact of avoiding or delaying progression to mCRPC on HRQ...


Treatment-resistant depression and major depression with suicide risk-The cost ...

Sousa, RD; Gouveia, Miguel; Nunes da Silva, Catarina; Maria Rodrigues, Ana; Cardoso, Graca; Antunes, Ana Filipa; Canhão, Helena

Funding The present work received support from Janssen-Cilag Farmacêutica, Lda, as an Unrestricted Grant. Janssen-Cilag had no role in the execution of the study, including analyses and interpretation of results.; Introduction: Treatment-Resistant Depression (TRD) and Major Depression with Suicide Risk (MDSR) are types of depression with relevant effects on the health of the population and a potentially signifi...


Custos indiretos do enfarte agudo do miocárdio em Portugal

Timóteo, Ana Teresa; Gouveia, Miguel; Soares, Cristina; Cruz Ferreira, Rui

Introduction: Cardiovascular disease, and particularly myocardial infarction (MI), carries a significant economic burden, through productivity losses (indirect costs) associated with temporary absence from work, that has not yet been adequately studied in Portugal. Our objective was to quantify the indirect costs of MI in the first year after admission. Methods: Consecutive patients admitted to a single center ...


The impact of osteoarthritis on early exit from work

Laires, Pedro A; Canhão, Helena; Maria Rodrigues, Ana; Eusébio, Mónica; Gouveia, Miguel; Branco, Jaime

BACKGROUND: Osteoarthritis (OA) is a leading cause of pain and disability, which may be a source of productivity losses. The objectives of this study were to describe the impact of OA, namely through pain and physical disability, on early exit from work and to calculate its economic burden. METHODS: We analysed data from the national, cross-sectional, population-based EpiReumaPt study (Sep2011-Dec2013) in which...


Can kidney deceased donation systems be optimized?

Domingos, Margarida; Gouveia, Miguel; Nolasco, Fernando Eduardo Barbosa; Pereira, João


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