11 documents found, page 1 of 2
Tumor Testing for Somatic and Germline BRCA1/BRCA2 Variants in Ovarian Cancer P...
Peixoto, A; Pinto, P; Guerra, J; Pinheiro, M; Santos, C; Pinto, C; Santos, R; Escudeiro, C; Bartosch, C; Canário, R; Barbosa, A; Gouveia, A; Petiz, ADeleterious variants in the BRCA1/BRCA2 genes and homologous recombination deficiency (HRD) status are considered strong predictors of response to poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi). The introduction of PARPi in clinical practice for the treatment of patients with advanced ovarian cancer imposed changes in the molecular diagnosis of BRCA1/BRCA2 variants. BRCA1/BRCA2 tumor testing by next-gen...
Endothelial Progenitor Cells influence acute and subacute stroke hemodynamics
Sargento-Freitas, J; Aday, S; Nunes, C; Cordeiro, M; Gouveia, A; Silva, F; Machado, C; Rodrigues, B; Santo, GC; Ferreira, C; Castelo-Branco, MBACKGROUND: Endothelial Progenitor Cells (EPCs) are a circulating stem cell population with in vivo capacity of promoting angiogenesis after ischemic events. Despite the promising preclinical data, their potential integration with reperfusion therapies and hemodynamic evolution of stroke patients is still unknown. Our aim was to determine the association of EPCs with acute, subacute and chronic hemodynamic feat...
Bilateral versus ipsilesional cortico-subcortical activity patterns in stroke s...
Vidal, AC; Banca, P; Pascoal, AG; Santo, GC; Sargento-Freitas, J; Gouveia, A; Castelo-Branco, MBackground Understanding of interhemispheric interactions in stroke patients during motor control is an important clinical neuroscience quest that may provide important clues for neurorehabilitation. In stroke patients, bilateral overactivation in both hemispheres has been interpreted as a poor prognostic indicator of functional recovery. In contrast, ipsilesional patterns have been linked with better motor out...
Cognitive impairment and magnetic resonance imaging correlates in primary progr...
Gouveia, A; Dias, SP; Santos, T; Rocha, H; Coelho, CR; Ruano, L; Galego, O; Diogo, MC; Seixas, D; Sá, MJ; Batista, SObjectives: To characterize cognitive impairment in primary progressive multiple sclerosis (PPMS) and to correlate the pattern of cognitive deficits with brain magnetic resonance imaging (MRI) volumetric data. Materials and methods: In a multicenter cross-sectional study, we recruited consecutive patients with PPMS as well as age, sex, and education level-matched healthy controls (HC). All participants underwen...
Cognitive Impairment and Magnetic Resonance Imaging Correlates in Primary Progr...
Gouveia, A; Dias, S; Santos, T; Rocha, H; Coelho, C; Ruano, L; Galego, O; Diogo, M; Seixas, D; Sá, MJ; Batista, SObjectives: To characterize cognitive impairment in primary progressive multiple sclerosis (PPMS) and to correlate the pattern of cognitive deficits with brain magnetic resonance imaging (MRI) volumetric data. Materials and methods: In a multicenter cross-sectional study, we recruited consecutive patients with PPMS as well as age, sex, and education level-matched healthy controls (HC). All participants underwen...
Recurrence in intracranial atherosclerotic disease: a stenosis-based analysis
Gouveia, A; Sargento-Freitas, J; Penetra, J; Silva, F; Machado, C; Cordeiro, G; Cunha, LBACKGROUND: Intracranial atherosclerotic disease is a common cause of stroke; its incidence and prevalence vary widely by ethnicity. The aim of our study was to analyze the recurrence rate of cerebrovascular events in patients with symptomatic and asymptomatic intracranial stenosis (IS). METHODS: We conducted a historical cohort study including all patients admitted in our hospital for stroke or transient ische...
Prevalência de Obstrução numa População Exposta ao Fumo do Tabaco - Projecto PN...
Reis Ferreira, JM; Matos, MJ; Rodrigues, F; Belo, A; Brites, H; Cardoso, J; Simão, P; Moutinho dos Santos, J; Almeida, J; Gouveia, A; Bárbara, CA espirometria não atingiu ainda a divulgação que se justificaria em patologia respiratória, ou indivíduos que se encontram em risco relativamente a esta patologia, cujo diagnóstico é insuficiente, havendo um escasso conhecimento, e consequente controlo, dos custos atribuíveis a estas doenças, com destaque para a doença pulmonar obstrutiva crónica (DPOC). O PNEUMOBIL, iniciativa que visa esta divulgação entre f...
Coronary artery disease, myocardial perfusion and ventricular function in Q-wav...
Macieira-Coelho, E; Garcia-Alves, M; da Costa, B; Cantinho, G; Pedro, P; Dionisio, I; Gouveia, A; de Padua, FControversy remains in considering non-Q wave myocardial infarction (NQMI) a distinct pathophysiological entity of Q wave myocardial infarction (QMI). In order to analyze the severity of coronary artery disease, extension of myocardial scar or myocardial ischemia and ventricular function, 78 consecutive patients with QMI and 32 with NQMI, mean age 55.4 +/- 8.5, not submitted to thrombolytic therapy, were studie...
The risk of seroconversion in surgeons of the hepatitis B, hepatitis C and huma...
Mineiro, J; Catela, A; Pedro, M; Gouveia, A; Gomes, A RThe prevalence of hepatitis B surface antigen (HBs Ag) and antibody to hepatitis C virus (HCV) and human immunodeficiency virus (HIV) was determined in the serum specimens of 288 patients treated surgically in the orthopaedic department of an urban public teaching hospital. The cumulative risk of HBV, HCV and HIV seroconversion for an orthopaedic surgeon during the surgical career span was calculated. We found ...
Prevalence of chronic hepatic disease in Portugal. Apropos of a review carried ...
Valente, A I; Almeida, A; Gouveia, A; Serejo, F; Ramalho, F; Baptista, A; Saragoça, A; Moura, M CThe chronic elevation of Aminotransferases is one of the most frequent indications for percutaneous Liver Biopsy (LB). From a retrospective study of LB performed in the Hepatology liver Unit of Santa Maria Hospital, between 1989 and 1993, we correlated the histologic diagnosis with the etiology of liver disease, sex, age and the Aspartate aminotransferase/Alanine aminotransferase (AST/ALT) and Gama-Glutamyl tra...