5 documents found, page 1 of 1
Metformin reverses infertility in a mouse model of endometriosis: unveiling dis...
Neto, AC; Botelho, M; Rodrigues, AR; Lamas, S; Araújo, B; Guimarães, JT; Gouveia, AM; Almeida, H; Neves, D" Research question: Does metformin reverse endometriosis-associated infertility? Design: Endometriosis was induced by transplanting uterus fragments from B6CBAF1 mice into recipients of the same strain. The mice were divided into groups: endometriosis (End, n = 24), sham-operated (Sham, n = 12), endometriosis with metformin (0.5mg/ml) orally administered for 3 months (EndMet, n = 21) and sham-operated metformi...
Cumulative Effect of Cardiovascular Risk Factors on Regulation of AMPK/SIRT1-PG...
Pereira, AS; Gouveia, AM; Tomada, N; Rodrigues, AR; Neves, DCardiovascular disease risk factors (CVDRF), especially diabetes mellitus (DM), disrupt oxidative stress response. This condition underlies endothelial dysfunction, early manifested in men as erectile dysfunction. The current study is aimed at elucidating the impact of CVDRF in the oxidation responsive AMPK/SIRT1-PGC-1-SIRT3 pathway and related miRNAs in the human corpus cavernosum. Human penile tissue fragment...
Energy restriction, exercise and atorvastatin treatment improve endothelial dys...
Rocha, B; Rodrigues, AR; Tomada, I; Martins, MJ; Guimarães, J; Gouveia, AM; Almeida, H; Neves, DBackground: Endothelial dysfunction underlies cardiovascular disease that frequently affects aged individuals. Characterized by local decrease in nitric oxide, it results from down-regulation of endothelial nitric oxide synthase (eNOS) expression/activity. Aiming to elucidate the molecular mechanisms involved in age-related endothelial dysfunction and to unveil potential therapeutic targets, we tested how diet ...
Recomendações para Análise Mutacional em Tumores do Estroma Gastrointestinal (G...
Lopes, JM; Soares, M; Gouveia, AM; Barroso, S; Cravo, M; Mansinho, H; Penedo, L; Sá, A; Santos, LL; Teixeira, JAThe authors outline recommendations for the mutational analysis of GISTs unanimously approved by a multidisciplinary group on July 20th, 2012. The mutational status of KIT and PDGFRA allows identifying therapeutic targets to tyrosine kinase inhibitors (TKIs), and therefore, the safe clinical practice in the biotherapy decisions for patients with GISTs should include the analysis of the mutational status. The mu...
Recomendações para Análise Mutacional em Tumores do Estroma Gastrointestinal (G...
Lopes, JM; Soares, M; Gouveia, AM; Barroso, S; Cravo, M; Mansinho, H; Penedo, J; Sá, A; Santos, LL; Teixeira, JAOs autores apresentam as recomendações para a análise mutacional de GISTs, aprovadas por unanimidade por um grupo multidisciplinar em 20 de Julho de 2012. O estado mutacional de genes como o KIT e o PDGFRA permite identificar alvos terapêuticos para inibidores da tirosinacínase (ITKs) e, por isso, a boa prática clínica nas decisões bioterapêuticas de doentes com GISTs deve incluir a análise do estado mutacional...