77 documents found, page 1 of 8
Cold Agglutinin Syndrome and Hemophagocytic Lymphohistiocytosis: An Unusual Com...
Sousa Nunes, B; Gouveia, C; Kjollerstrom, P; Farela Neves, JAutoimmune hemolytic anemia (AIHA) and hemophagocytic lymphohistiocytosis (HLH) are rare complications of infectious mononucleosis. The authors describe a 12-year-old male with acute infectious mononucleosis, hepatitis, cholestasis, and an autoimmune hemolytic disorder caused by cold agglutinins IgM (anti-i specificity). Clinical deterioration with persistent fever, anemia, and hepatosplenomegaly was consistent...
Uncovering the burden of Influenza in children in Portugal, 2008-2018
Caldas Afonso, A; Gouveia, C; Januário, G; Carmo, M; Lopes, H; Bricout, H; Gomes, C; Froes, FBackground Despite their higher risk of developing severe disease, little is known about the burden of influenza in Portugal in children aged < 5 years old. This study aims to cover this gap by estimating the clinical and economic burden of severe influenza in children, in Portugal, during ten consecutive influenza seasons (2008/09-2017/18). Methods We reviewed hospitalizations in children aged < 5 years old us...
Prospective Study of Loss of Health-Related Quality Adjusted Life Years in Chil...
Rodrigues, F; Marlow, R; Gouveia, C; Correia, P; Brett, A; Silva, C; Gameiro, I; Rua, I; Dias, J; Martins, M; Diogo, R; Lopes, T; Hipólito, EIntroduction and aims: Although usually benign, varicella can lead to serious complications and sometimes long-term sequelae. Vaccines are safe and effective but not yet included in immunisation programmes in many countries. We aimed to quantify the impact on health-related quality of life (HRQoL) in terms of quality-adjusted life years (QALY) in children with varicella and their families, key to assessing cost...
Hemophagocytic Lymphohistiocytosis in an Adolescent with NLRP12‐Related Autoinf...
Hormigo, I; Valente Pinto, M; Cordeiro, AI; Henriques, C; Martins, C; Parente Freixo, J; Conde, M; Gouveia, C; Farela Neves, J
Sustained Increase of Paediatric Invasive Streptococcus Pyogenes Infections Dom...
Gouveia, C; Bajanca-Lavado, MP; Mamede, R; Araújo Carvalho, A; Rodrigues, F; Melo-Cristino, J; Ramirez, M; Friães, Aince autumn 2022, observed numbers of paediatric invasive group A Streptococcus infections in Portugal (n = 89) were higher than in pre-COVID-19 seasons. Between September 2022 and May 2023, the dominant diagnoses were pneumonia (25/79), mostly with empyema (20/25), and sepsis (22/79). A number of cases required admission to intensive care (27/79) and surgery (35/79), and the case fatality rate was 5.1% (4/79)....
Recurrent Pyogenic Infections Caused by a Movel Gln1420* Mutation in the C3 Gene
Coelho, PS; Gouveia, C; Pinto, MV; Neves, C; Cordeiro, AI; Neves, JFC3 is a crucial protein of the complement system. Congenital C3 deficiency is extremely rare and manifests through recurrent, severe infections and should always be considered as a differential diagnosis of recurrent pyogenic infections. We report a case of a patient with a novel C3 gene mutation, responsible for complete C3 deficiency with impaired complement system activation and recurrent infections.
Osteoarticular Infections in Infants Under 3 Months of Age
Branco, J; Duarte, M; Norte, S; Arcangelo, J; Alves, P; Brito, M; Tavares, D; Gouveia, CBackground: Acute osteoarticular infections (OAI) in infants under 3 months of age (≤3M) are rare and remain a diagnostic challenge. Orthopedic complications and functional sequelae have been less well described in this age group. Our aims were to evaluate trends in aetiology, management, and outcomes of OAI ≤ 3M, and to compare these younger children who have OAI with older children. Methods: A longitudinal ob...
COVID-19 in a Tertiary Paediatric Centre in Portugal: a Single-Centre Retrospec...
Milheiro Silva, T; Garcia, AM; Gouveia, C; Candeias, F; Brito, MJObjective: To describe the demographic, clinical, laboratory and imaging features of the first 300 SARS-CoV-2-infected children presenting to a tertiary paediatric centre in Portugal. Design: Single-centre, retrospective, descriptive study of paediatric patients who had a confirmed SARS-CoV-2 infection from 7 March to 20 September 2020. Setting: Tertiary paediatric referral centre (Hospital Dona Estefânia, Lisb...
Osteomielitis Hematógena Aguda en Lisboa: Asociación con Miositis y Artritis In...
Gouveia, C; Branco, J; Norte, S; Arcangelo, J; Alves, P; Pinto, M; Tavares, DIntroduction: Despite the current trend towards less aggressive therapeutic approaches, acute haematogenous osteomyelitis (AHO) continues to be a challenge and is associated with significant morbidity worldwide. Our aim was to determine if 80% compliance with current protocol was achieved, identify complications and associated risk factors and analyse trends in aetiology and management of AHO in children. Metho...
Distinguishing Kingella kingae from Pyogenic Acute Septic Arthritis in Young Po...
Gouveia, C; Subtil, A; Norte, S; Arcangelo, J; Santos, MA; Corte-Real, R; Simões, MJ; Canhão, H; Tavares, DBackground: We aim to identify clinical and laboratorial parameters to distinguish Kingella kingae from pyogenic septic arthritis (SA). (2) Methods: A longitudinal, observational, single-centre study of children < 5 years old with microbiological positive SA admitted to a paediatric hospital from 2013-2020 was performed. Clinical and laboratorial data at admission and at 48 h, as well as on treatment and evolut...