33 documents found, page 1 of 4
miR-21-5p dysregulation is associated with gut microbiota dysbiosis and pro-onc...
Santos, André Anastácio; Pires, David; Marques, Vanda; Alesina, Nicole; Rodrigues, Pedro Miguel; Bravo, Ana Catarina; Gouveia, Catarina; Saraiva, SusanaBackground: Primary sclerosing cholangitis (PSC) is a chronic liver disease frequently associated with inflammatory bowel disease (IBD) and increased risk of colorectal cancer (CRC). Despite the strong association, the underlying mechanisms linking PSC-IBD, gut inflammation, and neoplastic potential remain unclear. This study explores the role of miR-21-5p dysregulation, gut microbiota dysbiosis, and pro-oncoge...
Reactive Infectious Mucocutaneous Eruption: A Rising Enigma
Lage, Joana; Lemos, Ana; Garcia, Ana; Silva, Tiago; Gouveia, CatarinaReactive infectious mucocutaneous eruption is a rare condition that predominantly occurs in pediatric patients following a respiratory infection, most commonly caused by Mycoplasma pneumoniae. It is characterized by prominent mucositis, usually with minimal or absent skin involvement. We present the case of a nine-year-old male admitted with severe oral mucositis and a penile lesion compromising bladder emptyin...
Enterovírus não-polio e infeções do sistema nervoso central em crianças: avalia...
Palminha, Paula; Neves, Raquel; Ribeiro, Carlos; Garcia, Ana Margarida; Fontes, Inês Sousa; Gouveia, Catarina; Corte-Real, RitaOs enterovírus não-polio permanecem como os principais agentes patogénicos do sistema nervoso central (SNC) em todo o mundo, especialmente em crianças com idade inferior a 5 anos, causando desde doença ligeira a quadros graves que podem evoluir para desfechos fatais. Entre 2023 e 2024 foram analisadas no INSA fezes de 327 crianças com suspeita de infeção por enterovírus. O diagnóstico laboratorial incluiu a det...
Primary bile acid shapes peripheral immunity in inflammatory bowel disease-asso...
Santos, André A.; Pires, David; Marques, Vanda; Alesina, Nicole; Herraez, Elisa; Roudnický, Pavel; Rodrigues, Pedro M.; Godinho-Santos, AnaPrimary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease often associated with underlying inflammatory bowel disease (IBD). This study investigates how PSC predisposes individuals to altered inflammatory immune responses compared with IBD alone. A case–control study was conducted with a cohort of 75 patients, including 16 with PSC (14 with concomitant IBD), 39 with IBD alone, and 20 controls....
Prediction of Hepatocellular Carcinoma in a Portuguese Population after Hepatit...
Mascarenhas, André; Serrazina, Juliana; Bronze, Sérgio; Cortez-Pinto, Helena; Presa, José; Barreira, Ana; Carrola, Paulo; Vara-Luiz, FranciscoIntroduction: Chronic infection with hepatitis C virus (HCV) causes 25% of hepatocellular carcinoma (HCC) cases worldwide, a major cause of morbimortality even after sustained virologic response (SVR). Universal screening to all patients with advanced liver fibrosis is currently recommended. A risk-based strategy could improve the detection rate of early HCC and diminish the surveillance burden. Although severa...
Inefficiency of Kocher and Caird’s Criteria in Septic Arthritis of the Hip Due ...
De Marco, Giacomo; Vazquez, Oscar; Cochard, Blaise; Foland, Piotr; Meinzer, Ulrich; Mallet, Cindy; Ilharreborde, Brice; Haumont, EdouardPublisher Copyright: © 2025 by the authors.; In children under 4, septic arthritis of the hip (SAH) caused by Kingella kingae (SAH-KK) can be misdiagnosed, as it does not meet classic septic joint criteria (fever > 38.5°, pain, limited range of motion, and inability to bear weight). The objective of this study was to report clinical and paraclinical characteristics in a large cohort of children with confirmed S...
Grapevine subtilisin-like proteases and Plasmopara viticola serine protease inh...
Gouveia, CatarinaGrapevine (Vitis vinifera L. subsp. sativa) is one of the most cultivated fruit crops worldwide. However, is highly susceptible to several pathogens which poses a severe threat to production yields. One of the most devastating diseases is the grapevine downy mildew caused by the obligate biotrophic oomycete Plasmopara viticola (Berk. & M.A. Curtis) Berl. & De Toni. This pathogen was introduced in Europe in the ...
Cold Agglutinin Syndrome and Hemophagocytic Lymphohistiocytosis: An Unusual Com...
Sousa Nunes, Beatriz; Gouveia, Catarina; Kjollerstrom, Paula; Farela Neves, JoãoAutoimmune hemolytic anemia (AIHA) and hemophagocytic lymphohistiocytosis (HLH) are rare complications of infectious mononucleosis. The authors describe a 12-year-old male with acute infectious mononucleosis, hepatitis, cholestasis, and an autoimmune hemolytic disorder caused by cold agglutinins IgM (anti-i specificity). Clinical deterioration with persistent fever, anemia, and hepatosplenomegaly was consistent...
Sustained increase of paediatric invasive Streptococcus pyogenes infections dom...
Gouveia, Catarina; Bajanca-Lavado, Maria Paula; Mamede, Rafael; Araújo Carvalho, Ana; Rodrigues, Fernanda; Melo-Cristino, José; Ramirez, MarioSince autumn 2022, observed numbers of paediatric invasive group A Streptococcus infections in Portugal (n = 89) were higher than in pre-COVID-19 seasons. Between September 2022 and May 2023, the dominant diagnoses were pneumonia (25/79), mostly with empyema (20/25), and sepsis (22/79). A number of cases required admission to intensive care (27/79) and surgery (35/79), and the case fatality rate was 5.1% (4/79)...
Children engaged in musical creation
Coelho, Ana Raquel; Pereira, Ana Isabel; Cordeiro, Tiago; Cintrão, Nuno; Machado, Susana; Reis, Bruno; Lucas, Olívia; Gouveia, CatarinaConservatório de Música de Sintra has been founded as a nonprofit association and music school since 1974, working with different ages from 6 month to 99 years old. Established as an official music school since 1982, more recently, in 2019, we have extended the educational offer with kindergarten and in 2021 to primary school. One of our school 's main goals is to engage children in democratic practices in the ...