3 documents found, page 1 of 1
Da Indústria ao Ensino
César, Adriana; Gomes, Lia; Gouveia, Liliana; Frade, José Manuel C.B.
Association of a genetic variant in the ALOX5AP with higher risk of ischemic st...
Domingues-Montanarie, Sophie; Fernández-Cadenas, Israel; Rio-Espinola, Alberto del; Corbeto, Natalia; Krug, Tiago; Manso, Helena; Gouveia, LilianaBackground: Variants in the 5-lipoxygenase-activating protein (ALOX5AP) and phosphodiesterase 4D (PDE4D) genes have first been associated with ischemic stroke (IS) through whole-genome linkage screens. However, association studies obtained conflicting results. We aimed to investigate the contribution of selected single nucleotide polymorphisms (SNPs) in these genes for the first time in a large Iberian populati...
Mitochondrial haplogroup H1 is protective for ischemic stroke in portuguese pat...
Rosa, Alexandra; Fonseca, Benedita V.; Krug, Tiago; Manso, Helena; Gouveia, Liliana; Albergaria, Isabel; Gaspar, Gisela; Correia, ManuelBackground: The genetic contribution to stroke is well established but it has proven difficult to identify the genes and the disease-associated alleles mediating this effect, possibly because only nuclear genes have been intensely investigated so far. Mitochondrial DNA (mtDNA) has been implicated in several disorders having stroke as one of its clinical manifestations. The aim of this case-control study was to ...