21 documents found, page 1 of 3
Atherosclerosis in the Primary Health Care Setting: A Real-Word Data Study
Ascenção, R; Alarcão, J; Araújo, F; Costa, J; Fiorentino, F; Gil, V; Gouveia, M; Lourenço, F; Mello e Silva, A; Vaz Carneiro, A; Borges, MIntroduction and objectives: To characterize patients with atherosclerosis, a disease with a high socioeconomic impact, in the Lisbon and Tagus Valley Health Region. Methods: A cross-sectional observational study was carried out through the Lisbon and Tagus Valley Regional Health Administration primary health care database, extracting data on the clinical and demographic characteristics and resource use of adul...
Indirect Costs of Myocardial Infarction in Portugal
Timóteo, AT; Gouveia, M; Soares, C; Cruz Ferreira, RIntroduction: Cardiovascular disease, and particularly myocardial infarction (MI), carries a significant economic burden, through productivity losses (indirect costs) associated with temporary absence from work, that has not yet been adequately studied in Portugal. Our objective was to quantify the indirect costs of MI in the first year after admission. Methods: Consecutive patients admitted to a single center ...
The burden of atherosclerosis in Portugal
Costa, J; Alarcão, J; Araujo, F; Ascenção, R; Caldeira, D; Fiorentino, F; Gil, V; Gouveia, M; Lourenço, F; Mello E Silva, A; Sampaio, F; Vaz-Carneiro, AAims: This paper sought to estimate the burden of disease attributable to atherosclerosis in mainland Portugal in 2016. Methods and results: The burden of atherosclerosis was measured in disability-adjusted life years (DALY) following the latest 2010 Global Burden of Disease (GBD) methodology. DALYs were estimated as the sum of years of life lost (YLL) with years lived with disability (YLD). The following clini...
Free But Valuable: The Economic Significance of Services Provided by Portuguese...
Gouveia, M; Machado, F; Mendes, Z; Gouveia, MObjectivesBesides dispensing medicines, pharmacies render other services including advice on health problems and on the best use of medicines; detecting problems in patients’ medications; counseling on nutrition, etc. The majority of these services is free. Up to now, the volume of these services in Portugal were unknown. This paper presents 2008 estimates for the volume of pharmacy interventions and their econ...
Economic Evaluation of the Portuguese Needle Exchange Program in Community Phar...
Gouveia, M; Carneiro, AV; Costa, S; Guerreiro, J; Cary, M; Jesus, G; Gouveia, M; Borges, MObjectivesTo conduct a cost-effectiveness analysis comparing two scenarios of the Needle Exchange Program (NEP) in Portugal: with and without community pharmacies (CP). Methods Health gains were measured by the number of HIV and HCV infections avoided. The number of infections in each scenario was estimated based on a standard model in the literature (Jacobs et al, 1994) calibrated to the national epidemiologic...
Dispensing of Specialist HIV Drugs in Community Pharmacies-Evaluation of Effect...
Gouveia, M; Rodrigues, AT; Borges, M; Costa, J; Fiorentino, F; Jesus, J; Rodrigues, AT; Cary, M; Guerreiro, J; Heudtlass, P; Costa, S; Carneiro, AVBackgroundThe prospect of chronic HIV patients obtaining their ART medication in community settings has considerable interest for health authorities. In Portugal, the Health Ministry promoted a pilot study randomizing the dispensing of ART therapy to hospital pharmacies and to community pharmacies in order to assess the impact of a transfer of dispensing from the current hospital setting. This study “piggy back...
Cost-Effectiveness of the 13-Valent Pneumococcal Conjugate Vaccine in Adults in...
Gouveia, M; Jesus, G; Inês, M; Costa, J; Borges, MThe burden of pneumococcal disease in adults is substantial from a social and economic point of view. This study assessed the cost-effectiveness of the 13-valent pneumococcal conjugate vaccine (PCV13) for the prevention of invasive pneumococcal disease and pneumococcal pneumonia in adults versus "no vaccination" and versus vaccination with the 23-valent pneumococcal polysaccharide vaccine (PPSV23). A Markov mod...
The antioxidants resveratrol and N-acetylcysteine enhance anthelmintic activity...
Gouveia, M; Brindley, P; Azevedo, C; Gärtner, F; Costa, JMC; Vale, NBackground: Treatment of schistosomiasis has relied on the anthelmintic drug praziquantel (PZQ) for more than a generation. Despite its celebrated performance for treatment and control of schistosomiasis and other platyhelminth infections, praziquantel has some shortcomings and the inability of this drug to counteract disease sequelae prompts the need for novel therapeutic strategies. Methods: Using a host-para...
Combination anthelmintic/antioxidant activity against schistosoma mansoni
Gouveia, M; Brindley, P; Rinaldi, G; Gärtner, F; Costa, J; Vale, NSchistosomiasis is a major neglected tropical disease. Treatment for schistosomiasis with praziquantel (PZQ), which is effective against the parasite, by itself is not capable to counteract infection-associated disease lesions including hepatic fibrosis. There is a pressing need for novel therapies. Due to their biological properties, antioxidant biomolecules might be useful in treating and reverting associated...
Infection with carcinogenic helminth parasites and its production of metabolite...
Gouveia, M; Brindley, P; Rinaldi, G; Gärtner, F; Costa, J; Vale, NBackground: Infections classified as group 1 biological carcinogens include the helminthiases caused by Schistosoma haematobium and Opisthorchis viverrini. The molecular mediators underlying the infection with these parasites and cancer remain unclear. Although carcinogenesis is a multistep process, we have postulated that these parasites release metabolites including oxysterols and estrogen-like metabolites th...