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Activity of Combinations of Antioxidants and Anthelmintic Drugs against the Adu...
Gouveia, MJ; Brindley, PJ; Gärtner, F; Vale, NSchistosomiasis remains a major neglected tropical disease. The treatment and control of schistosomiasis rely on a single drug, praziquantel (PZQ). Despite its efficacy, treatment with PZQ presents some major drawbacks including an inability of the chemotherapy to reverse disease-induced fibrosis and the prospect of the emergence of drug resistance. Here, we investigated a novel therapeutic approach with antiox...
Inhibition of the formation in vitro of putatively carcinogenic metabolites der...
Gouveia, MJ; Nogueira, V; Araújo, B; Gärtner, F; Vale, NInfections caused by Schistosoma haematobium and Opisthorchis viverrini are classified as carcinogenic. Although carcinogenesis might be a multifactorial process, it has been postulated that these helminth produce/excrete oxysterols and estrogen-like metabolites that might act as initiators of their infection-associated carcinogenesis. Current treatment and control of these infections rely on a single drug, pra...
Anxiety and Depression in the Portuguese Older Adults: Prevalence and Associate...
de Sousa, RD; Rodrigues, AM; Gregório, Maria João; Branco, JD; Gouveia, MJ; Canhao, H; Dias, SSAnxiety and depression in the elderly individuals have been studied around the world, and some authors consider them among the most serious problems faced by modern societies. With recent economic crisis-very important in Southern European countries-isolation, loneliness, and exclusion of the active society, mental problems are probably raising and associated with distinct factors. In this cross-sectional analy...
Brooke-Spiegler Syndrome - an underrecognized cause of multiple familial scalp ...
Pinho, AC; Gouveia, MJ; Gameiro, AR; Cardoso, JC; Gonçalo, MargaridaBACKGROUND: Brooke-Spiegler syndrome (BSS) is probably an underdiagnosed genodermatosis that predisposes for the development of cylindromas, spiradenomas and trichoepitheliomas mainly of the head and neck. Wide phenotypic variability regarding the number and type of lesions can be observed within a family. Mutations of the CYLD gene are identified in the vast majority of cases and play a key role in BSS pathoge...