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Targeting circulating labile heme as a defense strategy against malaria
Ramos, Susana; Jeney, Viktoria; Figueiredo, Ana; Paixão, Tiago; Sambo, Maria Rosário; Quinhentos, Vatúsia; Martins, Rui; Gouveia, ZéliaSevere presentations of malaria emerge as Plasmodium (P.) spp. parasites invade and lyse red blood cells (RBC), producing extracellular hemoglobin (HB), from which labile heme is released. Here, we tested whether scavenging of extracellular HB and/or labile heme, by haptoglobin (HP) and/or hemopexin (HPX), respectively, counter the pathogenesis of severe presentations of malaria. We found that circulating labil...
Characterization of Plasma Labile Heme in Hemolytic Conditions
Gouveia, Zélia; Carlos, Ana Rita; Yuan, Xiaojing; Aires-da-Silva, Frederico; Stocker, Roland; J. Maghzal, Ghassan; Leal, Sónia S.; Gomes, Cláudio M.Extracellular hemoglobin (Hb), a byproduct of hemolysis, can release its prosthetic heme groups upon oxidation. This produces metabolically active heme that is exchangeable between acceptor proteins, macromolecules and low molecular weight ligands, termed here labile heme. As it accumulates in plasma labile heme acts in a pro-oxidant manner and regulates cellular metabolism while exerting pro-inflammatory and c...
Heme Cytotoxicity and the Pathogenesis of Immune-Mediated Inflammatory Diseases
Larsen, Rasmus; Gouveia, Zélia; Soares, Miguel P.; Gozzelino, RaffaellaHeme, iron (Fe) protoporphyrin IX, functions as a prosthetic group in a range of hemoproteins essential to support life under aerobic conditions. The Fe contained within the prosthetic heme groups of these hemoproteins can catalyze the production of reactive oxygen species. Presumably for this reason, heme must be sequestered within those hemoproteins, thereby shielding the reactivity of its Fe-heme. However, u...
The alternative oxidase family of Vitis vinifera reveals an attractive model to...
Costa, José Hélio; Fernandes de Melo, Dirce; Gouveia, Zélia; Cardoso, Hélia; Peixe, Augusto; Arnholdt-Schmitt, Birgit'Genomic design' refers to the structural organization of gene sequences. Recently, the role of intron sequences for gene regulation is being better understood. Further, introns possess high rates of polymorphism that are considered as the major source for speciation. In molecular breeding, the length of gene-specific introns is recognized as a tool to discriminate genotypes with diverse traits of agronomic int...