3 documents found, page 1 of 1
Searching for new strategies against biofilm infections: Colistin-AMP combinati...
Jorge, Paula; Grzywacz, Daria; Kamysz, Wojciech; Lourenço, Anália; Pereira, Maria OlíviaAntimicrobial research is being pressured to look for more effective therapeutics for the ever-growing antibiotic-resistant infections, and antimicrobial peptides (AMP) and antimicrobial combinations are promising solutions. This work evaluates colistin-AMP combinations against two major pathogens, Pseudomonas aeruginosa and Staphylococcus aureus, encompassing non- and resistant strains. Colistin (CST) combined...
Co-immobilization of Palm and DNase I for the development of an effective anti-...
Alves, D.; Magalhães, Andreia; Grzywacz, Daria; Neubauer, Damian; Kamysz, Wojciech; Pereira, Maria OlíviaBiomaterial-associated infections, in particular, catheter-associated infections (CAI) are a major problem in clinical practice due to their ability to resist antimicrobial treatment and the host immune system. This study aimed to co-immobilize the antimicrobial lipopeptide Palm and the enzyme DNase I to introduce both antimicrobial and anti-adhesive functionalities to polydimethylsiloxane (PDMS) material, usin...
Anti-biofilm peptide combinations against Pseudomonas aeruginosa and Staphyloco...
Jorge, Paula Alexandra Silva; Grzywacz, Daria; Kamysz, Wojciech; Lourenço, Anália; Pereira, M. O.Today, we are facing a major challenge regarding the development of new strategies and the discovery of new compounds with effective antimicrobial outcomes. The emergence of resistance is a preoccupant health threat and conventional antibiotics are being rendered ineffective [1]. Specifically, biofilm related infections are becoming a serious threat, being highly related to chronic infections but also nosocomia...