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Interactions between Insomnia, Sleep Disordered Breathing and Cardiometabolic R...

Meira e Cruz, Miguel; Gozal, David; Salles, Cristina; Rocha, Isabel; Ettlin, Dominik

The existence of intersected pathways between the mechanisms of insomnia, sleep-disordered breathing and persistent/chronic pain has been documented. Such concurrence will eventually contribute to a higher burden of cardiometabolic diseases, a main cause of death worldwide. The aim of this study was to evaluate the interactions between insomnia, sleep-disordered breathing, cardiometabolic risk, and psychosocial...

Date: 2025   |   Origin: Acta Médica Portuguesa

Interactions between insomnia, sleep disordered breathing and cardiometabolic r...

Meira e Cruz, Miguel; Gozal, David; Salles, Cristina; Rocha, Isabel; Ettlin, Dominik

The existence of intersected pathways between the mechanisms of insomnia, sleep-disordered breathing and persistent/chronic pain has been documented. Such concurrence will eventually contribute to a higher burden of cardiometabolic diseases, a main cause of death worldwide. The aim of this study was to evaluate the interactions between insomnia, sleep-disordered breathing, cardiometabolic risk, and psychosocial...


Escalation of sleep disturbances amid the COVID-19 pandemic : a cross-sectional...

Mandelkorn, Uri; Genzer, Shir; Choshen-Hillel, Shoham; Reiter, Joel; Meira e Cruz, Miguel; Hochner, Hagit; Kheirandish-Gozal, Leila; Gozal, David

Study objectives: The stress imposed by the COVID-19 pandemic and ensuing social isolation could adversely affect sleep. As sleep problems may persist and hurt health, it is important to identify which populations have experienced changes in sleeping patterns during the pandemic and their extent. Methods: In Study 1, 3,062 responders from 49 countries accessed the survey website voluntarily between March 26 and...


Putative contributions of circadian clock and sleep in the context of SARS-CoV-...

Meira e Cruz, Miguel; Miyazawa, Masaaki; Gozal, David

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the aetiological agent of the pandemic coronavirus disease 2019 (COVID-19), is a newly found member of the Coronaviridae family, and is closely related to, albeit with important differences from, SARS-CoV. It enters human cells through the binding of surface spike (S) glycoprotein with angiotensin-converting enzyme 2 (ACE2). The distal S1 subunit of ...



Fractional Exhaled Nitric Oxide Measurements and Screening of Obstructive Sleep...

Duarte, Ricardo L M; Rabahi, Marcelo F; Oliveira-e-Sá, Tiago; Magalhães-da-Silveira, Flavio J; Mello, Fernanda C Q; Gozal, David

PURPOSE: Obstructive sleep apnea (OSA) is a common condition characterized by repetitive collapse of the upper airways and intermittent oxygen desaturation, which may lead to airway inflammation. Here, we explored whether fractional exhaled nitric oxide (FeNO) levels provide a non-invasive screening tool of OSA. METHODS: Over a 3-month period, FeNO levels were measured in consecutive non-smoking patients referr...


Nocturnal oximetry-based evaluation of habitually snoring children

Hornero, Roberto; Kheirandish-Gozal, Leila; Gutiérrez-Tobal, Gonzalo C.; Philby, Mona F.; Alonso-Álvarez, María Luz; Álvarez, Daniel; Dayyat, Ehab A.

Rationale: The vast majority of children around the world undergoing adenotonsillectomy for obstructive sleep apnea-hypopnea syndrome (OSA) are not objectively diagnosed by nocturnal polysomnography because of access availability and cost issues. Automated analysis of nocturnal oximetry (nSpO2), which is readily and globally available, could potentially provide a reliable and convenient diagnostic approach for ...


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