4 documents found, page 1 of 1
Shielding of actin by the endoplasmic reticulum impacts nuclear positioning
Janota, Cátia; Pinto, Andreia; Pezzarossa, Anna; Machado, Pedro; Costa, Judite; Campinho, Pedro; Franco, Claudio; Gomes, EdgarNuclear position is central to cell polarization, and its disruption is associated with various pathologies. The nucleus is moved away from the leading edge of migrating cells through its connection to moving dorsal actin cables, and the absence of connections to immobile ventral stress fibers. It is unclear how these asymmetric nucleo-cytoskeleton connections are established. Here, using an in vitro wound assa...
Competition for endothelial cell polarity drives vascular morphogenesis in the ...
Barbacena, Pedro; Dominguez-Cejudo, Maria Angeles; Fonseca, Catarina; Gómez-González, Manuel; Faure, Laura M.; Zarkada, Georgia; Pena, AndreiaBlood-vessel formation generates unique vascular patterns in each individual. The principles governing the apparent stochasticity of this process remain to be elucidated. Using mathematical methods, we find that the transition between two fundamental vascular morphogenetic programs-sprouting angiogenesis and vascular remodeling-is established by a shift of collective front-to-rear polarity of endothelial cells ...
Competition for endothelial cell polarity drives vascular morphogenesis in the ...
Barbacena, Pedro; Dominguez-Cejudo, Maria; Fonseca, Catarina G.; Gómez-González, Manuel; Faure, Laura M.; Zarkada, Georgia; Pena, AndreiaBlood-vessel formation generates unique vascular patterns in each individual. The principles governing the apparent stochasticity of this process remain to be elucidated. Using mathematical methods, we find that the transition between two fundamental vascular morphogenetic programs—sprouting angiogenesis and vascular remodeling—is established by a shift of collective front-to-rear polarity of endothelial cells ...
Non-canonical Wnt signaling regulates junctional mechanocoupling during angioge...
Carvalho, Joana R.; Fortunato, Isabela C.; Fonseca, Catarina; Pezzarossa, Anna; Barbacena, Pedro; Dominguez-Cejudo, Maria AngelesMorphogenesis of hierarchical vascular networks depends on the integration of multiple biomechanical signals by endothelial cells, the cells lining the interior of blood vessels. Expansion of vascular networks arises through sprouting angiogenesis, a process involving extensive cell rearrangements and collective cell migration. Yet, the mechanisms controlling angiogenic collective behavior remain poorly underst...