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Modulation of oligodendrocyte differentiation and maturation by combined bioche...

Lourenço, T; Faria, JP; Bippes, C; Maia, J; Lopes-Da-Silva, J; Relvas, JB; Graõs, M

Extracellular matrix (ECM) proteins play a key role during oligodendrogenesis. While fibronectin (FN) is involved in the maintenance and proliferation of oligodendrocyte progenitor cells (OPCs), merosin (MN) promotes differentiation into oligodendrocytes (OLs). Mechanical properties of the ECM also seem to affect OL differentiation, hence this study aimed to clarify the impact of combined biophysical and bioche...

Date: 2016   |   Origin: Repositório Aberto da Universidade do Porto
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