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Therapeutic strategies for IVD regeneration through hyaluronan/SDF-1-based hydr...

Cunha, C; Pereira, CL; Ferreira, JR; Ribeiro-Machado, C; Grad, S; Santos, SG; Gonçalves, RM

Intervertebral disc (IVD) degeneration involves a complex cascade of events, including degradation of the native extracellular matrix, loss of water content, and decreased cell numbers. Cell recruitment strategies for the IVD have been increasingly explored, aiming to recruit either endogenous or transplanted cells. This study evaluates the IVD therapeutic potential of a chemoattractant delivery system (HAPSDF5...


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