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Synthesis, molecular docking studies, and larvicidal activity evaluation of new...
Mesquita, Rochelly da Silva; Kyrylchuk, Andrii; Grafova, Iryna A.; Kliukovskyi, Denys; Bezdudny, Andriy V.; Rozhenko, Alexander B.Anopheles darlingi is the main vector of malaria in Brazil, characterized by a high level of anthropophilia and endophagy. Imidacloprid, thiacloprid, and acetamiprid are the most widespread insecticides of the neonicotinoid group. However, they produce adverse effects on the non-target insects. Flupyradifurone has been marketed as an alternative to non-fluorinated neonicotinoids. Neonicotinoids containing trifl...
Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Me...
Comandolli-Wyrepkowski, Claudia Dantas; Grafova, Iryna; Naiff, Maricleide de Farias; Avella, Maurizio; Gentile, Gennaro; Grafov, Andrèi AndriyCurrent treatment of cutaneous leishmaniasis (CL) relies mainly on pentavalent antimonials salts and second-line drugs include pentamidine and amphotericin B, but these therapies have side effects and require parenteral administration. The aim of this work was to evaluate the topical formulations containing pentamidine isethionate (PI) in the experimental treatment of cutaneous leishmaniasis (CL). Golden hamste...
Nanoscaled hydrated antimony (V) oxide as a new approach to first-line antileis...
Franco, A. M.; Grafova, Iryna A.; Soares, Fabiane Veloso; Gentile, Gennaro; Wyrepkowski, Claudia D C; Bolson, Marcos A.; Sargentini, ÉzioBackground: Coordination compounds of pentavalent antimony have been, and remain, the first-line drugs in leishmaniasis treatment for >70 years. Molecular forms of Sb (V) complexes are commercialized as sodium stibogluconate (Pentostam®) and meglumine antimoniate (MA) (Glucantime®). Ever-increasing drug resistance in the parasites limits the use of antimonials, due to the low drug concentrations being administe...