2 documents found, page 1 of 1
Risk Calculators in Bipolar Disorder: A Systematic Review
Ribeiro, Joana Silva; Pereira, Daniela; Salagre, Estela; Coroa, Manuel; Santos Oliveira, Pedro; Santos, Vítor; Madeira, Nuno; Grande, IriaIntroduction: Early recognition of bipolar disorder improves the prognosis and decreases the burden of the disease. However, there is a significant delay in diagnosis. Multiple risk factors for bipolar disorder have been identified and a population at high-risk for the disorder has been more precisely defined. These advances have allowed the development of risk calculators to predict individual risk of conversi...
Gut microbiota, bacterial translocation, and interactions with diet : pathophys...
Slyepchenko, Anastasiya; Maes, Michael; Jacka, Felice N.; Köhler, Cristiano A.; Barichello, Tatiana; McIntyre, Roger S.; Berk, Michael; Grande, IriaBackground: Persistent low-grade immune-inflammatory processes, oxidative and nitrosative stress (O&NS), and hy- pothalamic-pituitary-adrenal axis activation are integral to the pathophysiology of major depressive disorder (MDD). The microbiome, intestinal compositional changes, and re-sultant bacterial translocation add a new element to the bi- directional interactions of the gut-brain axis; new evidence impli...