23 documents found, page 1 of 3
Metabolism-Targeted Therapy in NSCLC - A New Theranostics Inhalation Approach U...
Mendes, Cindy; Martins, Filipa; Granja, Sara; Gonçalves, Joana; Barros, Hélio; Casimiro, Teresa; Aguiar-Ricardo, Ana; Silva, Fernanda; Abreu, BrunaLung cancer is one of the most lethal cancers globally, primarily due to delayed diagnosis and lack of specific and effective therapy. Increased lactate production and consumption, along with cysteine metabolic reliance, are features identified in NSCLC in our recent studies. Cancer metabolic remodeling leads to excessive ROS production, triggering oxidative stress, promoting angiogenesis, causing cellular and ...
Glucose metabolism as a potential therapeutic target in Cytarabine-resistant ac...
Pereira-Vieira, Joana; Weber, Daniela D.; Silva, Sâmia; Barbosa-Matos, Catarina; Granja, Sara; Reis, Rui Manuel; Queirós, Odília; Ko, Young H.Altered glycolytic metabolism has been associated with chemoresistance in acute myeloid leukemia (AML). However, there are still aspects that need clarification, as well as how to explore these metabolic alterations in therapy. In the present study, we aimed to elucidate the role of glucose metabolism in the acquired resistance of AML cells to cytarabine (Ara-C) and to explore it as a therapeutic target. Resist...
In vitro and in vivo evaluation of novel chromeno[2,3-d]pyrimidinones as therap...
Carvalho, Luísa; Lima, Fábio Pedroso de; Cerqueira, Mónica; Silva, Ana; Pontes, Olívia; Oliveira-Pinto, Sofia; Guerreiro, Sara; Costa, Marta D.Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and the limited therapeutic options show poor efficacy in patients, associated to severe side effects and development of resistance. Considering that chromene-based scaffolds proved to be attractive candidates for cancer therapy, herein we prepared new chromeno[2,3-d]pyrimidinone derivatives by a simple two step procedure, sta...
Estudo da morfologia de tecidos sujeitos a embalsamamento por método de Thiel
Moniz, Diana; Granja, Sara; Paulino, SofiaIntrodução: As técnicas de embalsamamento são utilizadas, na atualidade, para a preservação do cadáver para o momento fúnebre e para disseções em contexto académico [1,2]. O método de embalsamamento de Thiel apresenta vantagens em relação a outros métodos de embalsamamento, uma vez que permite a retenção da coloração e flexibilidade do cadáver, com retenção permanente da mobilidade [3]. No entanto, leva a alter...
Estudo da morfologia de tecidos sujeitos a embalsamamento por método de Thiel
Moniz, Diana; Granja, Sara; Paulino, SofiaAs técnicas de embalsamamento são utilizadas, na atualidade, para a preservação do cadáver para o momento fúnebre e para disseções em contexto académico. O método de embalsamamento de Thiel apresenta vantagens em relação a outros métodos de embalsamamento, uma vez que permite a retenção da coloração e flexibilidade do cadáver, com retenção permanente da mobilidade. No entanto, leva a alterações morfológicas do ...
Molecular techniques for the neonatal screening of spinal muscular atrophy
Oliveira, Renata; Granja, Sara; Silva, Regina A.; Rocha, HugoSpinal muscular atrophy (SMA) is neurodegenerative disease mainly caused by the homozygous deletion of the functional telomeric survival motor neuron 1 gene (SMN1) exon 7. This absence causes a lack of the ubiquitous SMN protein which selectively destroys alfa motor neurons. Due to the disease severity, it is the leading genetic cause of infant death. The copy number of the centromeric SMN2 gene has an inverse ...
Targeting lysosomes in colorectal cancer: exploring the anticancer activity of ...
Ferreira, João C. C.; Granja, Sara; Almeida, Ana F.; Baltazar, Fátima; Gonçalves, M. Sameiro T.; Preto, Ana; Sousa, Maria JoãoColorectal cancer (CRC) has been ranked as one of the cancer types with a higher incidence and one of the most mortal. There are limited therapies available for CRC, which urges the finding of intracellular targets and the discovery of new drugs for innovative therapeutic approaches. In addition to the limited number of effective anticancer agents approved for use in humans, CRC resistance and secondary effects...
Combination therapy with CD147-targeted nanoparticles carrying phenformin decre...
Pereira-Nunes, Andreia; Ferreira, Helena Susana Costa Machado; Abreu, Sara; Guedes, Marta; Neves, N. M.; Baltazar, Fátima; Granja, SaraLung cancer is one of the most fatal cancers worldwide. Resistance to conventional therapies remains a hindrance to patient treatment. Therefore, the development of more effective anti-cancer therapeutic strategies is imperative. Solid tumors exhibit a hyperglycolytic phenotype, leading to enhanced lactate production; and, consequently, its extrusion to the tumor microenvironment. Previous data reveals that inh...
Combination therapy with CD147‐targeted nanoparticles carrying phenformin decre...
Pereira-Nunes, Andreia; Ferreira, Helena; Abreu, Sara; Guedes, Marta; Neves, Nuno M.; Baltazar, Fátima; Granja, Sara; Granja, SaraLung cancer is one of the most fatal cancers worldwide. Resistance to conventional therapies remains a hindrance to patient treatment. Therefore, the development of more effective anti-cancer therapeutic strategies is imperative. Solid tumors exhibit a hyperglycolytic phenotype, leading to enhanced lactate production; and, consequently, its extrusion to the tumor microenvironment. Previous data reveals that inh...
CINtec PLUS cytology as a cervical cancer screening test at the IPO of Porto
Alves, Ana; Lopes, Ana Paula; Granja, Sara; Quintela Vieira, Filipa; Silva, Regina AugustaCervical squamous cell carcinoma of the cervix is the fourth most common cancer between women and seventh globally. There are many women undergoing colposcopy without real need, so more effective screening tests are needed to decide who among HPV-positive women should receive additional diagnostic evaluation to avoid unnecessary colposcopies. So, this study is intended to evaluate CINtec PLUS cytology as a scre...