6 documents found, page 1 of 1
Structural brain splitting is a hallmark of Granulin-related frontotemporal dem...
Gazzina, Stefano; Grassi, Mario; Premi, Enrico; Alberici, Antonella; Benussi, Alberto; Archetti, Silvana; Gasparotti, Roberto; Bocchetta, MartinaFrontotemporal dementia associated with granulin (GRN) mutations presents asymmetric brain atrophy. We applied a Minimum Spanning Tree plus an Efficiency Cost Optimization approach to cortical thickness data in order to test whether graph theory measures could identify global or local impairment of connectivity in the presymptomatic phase of pathology, where other techniques failed in demonstrating changes. We ...
Soft Nanoonions: A Dynamic Overview onto Catanionic Vesicles Temperature-Driven...
Milcovich, Gesmi; Antunes, Filipe E.; Grassi, Mario; Asaro, FiorettaCatanionic vesicles are emerging interesting structures for bioapplications. They self-generate by a pairing of oppositely charged ionic surfactants that assemble into hollow structures. Specifically, the anionic-cationic surfactant pair assumes a double-tailed zwitterionic behavior. In this work, the multilamellar-to-unilamellar thermal transition of several mixed aqueous systems, with a slight excess of the a...
Recent advances in smart biotechnology: Hydrogels and nanocarriers for tailored...
Milcovich, Gesmi; Lettieri, Stefania; Antunes, Filipe E.; Medronho, Bruno; Fonseca, Ana C.; Coelho, Jorge F. J.; Marizza, Paolo; Perrone, FrancescaOver the past ten years, the global biopharmaceutical market has remarkably grown, with ten over the top twenty worldwide high performance medical treatment sales being biologics. Thus, biotech R&D (research and development) sector is becoming a key leading branch, with expanding revenues. Biotechnology offers considerable advantages compared to traditional therapeutic approaches, such as reducing side effects,...
A new look to non-Fickian diffusion
Ferreira, José Augusto; Grassi, Mario; Gudin͂o, Elias; Oliveira, Paula deIn this paper a non linear mathematical model to describe absorption phenomena in polymers is proposed. The model is established assuming that the diffusing penetrant causes a deformation which induces a viscoelastic stress responsible for a convective field. This convective field is defined to represent an opposition of the polymer to the Fickian diffusion. Several numerical examples show the effectiveness of ...
A mathematical model for controlled drug delivery in swelling polymers
Ferreira, José Augusto; Grassi, Mario; Gudin͂o, Elias; Oliveira, Paula deWe propose a one-dimensional model to describe the sorption of a solvent by a polymeric membrane, followed by polymer swelling and drug release. We assume that the solvent diffuses into the membrane and induces a stress driven diffusion, that causes a non-Fickian mass flux. We assume that the drug is present in two states (dissolved and undissolved) and that its transport occurs by Fickian diffusion and non-lin...
Bi-layered self-emulsifying pellets prepared by co-extrusion and spheronization
Iosio, Tamara; Voinovich, Dario; Grassi, Mario; Pinto, Joao F.; Perissutti, Beatrice; Zacchigna, Marina; Quintavalle, Ugo; Serdoz, FrancescaThe aim of this work was to produce by co-extrusion-spheronization pellets with two cohesive layers, one of them containing a self-emulsifying system for vinpocetine, a poorly water soluble model drug. Two layers were prepared: an inert layer of microcrystalline cellulose, lactose and water and a second one wetted with the self-emulsifying system. Different formulations of both layers were tested, evaluating th...