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Biocompatibility of a self-assembled crosslinkable hyaluronic acid nanogel

Pedrosa, Sílvia Santos; Pereira, Paula Alexandra Cunha; Correia, Alexandra; Moreira, Susana; Rocha, Huho; Gama, F. M.

Hyaluronic acid nanogel (HyA-AT) is a redox sensitive crosslinkable nanogel, obtained through the conjugation of a thiolated hydrophobic molecule to the hyaluronic acid chain. Engineered nanogel was studied for its biocompatibility, including immunocompatibility and hemocompatability. The nanogel did not compromise the metabolic activity or cellular membrane integrity of 3T3, microvascular endothelial cells, an...


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