17 documents found, page 1 of 2
The effects of methylparaben exposure on drinking water bacteria virulence and ...
Pereira, Ana; Grenho, Liliana; Gomes, Inês; Simões, ManuelBackground: Parabens, widely used as preservatives in personal care products, pose an increased global concern due to their impact on environmental microbial communities, particularly in drinking water (DW), and potential risks to public health. Among different parabens detected in drinking water distribution systems (DWDS), methylparaben (MP) is the most prevalent at elevated concentrations, raising serious he...
Morin-loaded chitosan-poloxamer hydrogel as an osteoinductive delivery system f...
Pereira, Jesse Augusto; Martin, Victor; Araújo, Rita; Grenho, Liliana; Gomes, Pedro; Marto, Joana; Fernandes, Maria Helena; Santos, CatarinaConsidering the search for new biocompatible intracanal medicaments that can preserve remaining cells and stimulate bone tissue repair in the periapical region, this study aimed to synthesize and characterize the physicochemical properties of morin-loaded chitosan-poloxamer hydrogel (MCP) as well as to evaluate its osteogenic potential. Morin hydrate (M) was loaded into chitosan-poloxamer (CP) hydrogel and the ...
Correlation of antioxidant and antibacterial activities of the aqueous Pinus pi...
Barros, Diana; Grenho, Liliana; Fernandes, Maria Helena; Gomes, Pedro Sousa; Fernandes, ÉliaThis study explores the antioxidant, antibacterial, and cytocompatibility properties of aqueous Pinus pinaster bark extract (PBE). PBE was prepared using two solvent systems—100% distilled water and 1% DMSO in aqueous solution—at a solid-to-liquid ratio of 1:20 (w/v), following ISO guidelines. Extract characterization included yield determination, FTIR analysis, quantification of total phenolic (TPC) and flavon...
Amination of polymeric braid structures to improve tendon healing: An experimen...
Peixoto, Tânia; Silva, Daniel; Rodrigues, Miguel; Neto, Miguel; Silva, Rui; Paiva, Maria C.; Grenho, Liliana; Fernandes, Maria Helena; Lopes, Maria A.Several polymers are researched for tendon repair as polyethylene terephthalate (PET) and polylactic acid (PLA). These are biocompatible and useful in scaffolding repair though with minimal success due to long-term failure. There is a need to improve such scaffolds’ design and physical–chemical nature. This work concerns surface functionalization of polymeric braids (PET and PLA) that fulfill the high mechanica...
Amination of polymeric braid structures to improve tendon healing: an experimen...
Peixoto, Tânia; Silva, Daniel; Rodrigues, Miguel; Neto, Miguel; Silva, Rui Ramos; Paiva, Maria C.; Grenho, Liliana; Fernandes, Maria HelenaSeveral polymers are researched for tendon repair as polyethylene terephthalate (PET) and polylactic acid (PLA). These are biocompatible and useful in scaffolding repair though with minimal success due to long-term failure. There is a need to improve such scaffolds' design and physical–chemical nature. This work concerns surface functionalization of polymeric braids (PET and PLA) that fulfill the high mechanica...
Efficacy and cytotoxicity of binary mixtures as root canal filling solvents
Ferreira, Inês; Grenho, Liliana; Gomes, Pedro; Braga, A. C.; Fernandes, Maria Helena; Lopes, Maria Ascensão; Pina-Vaz, IreneObjectives: This study reports the efficacy of two solvent mixtures on the dissolution of gutta-percha and AH Plus sealer, together with the cytotoxicity. Methods: Methyl ethyl ketone (MEK), orange oil, tetrachloroethylene, MEK/tetrachloroethylene (1:1), MEK/orange oil (1:1), and chloroform (control) were tested. Twelve groups (<i>n</i> = 15) of standardized stainless-steel molds filled with softened gutta-perc...
Influence of PLLA/PCL/HA scaffold fiber orientation on mechanical properties an...
Siqueira, Lilian de; Ribeiro, Nilza; Paredes, Maria B. A.; Grenho, Liliana; Cunha-Reis, Cassilda; Trichês, Eliandra S.; Fernandes, Maria H.Scaffolds based on aligned and non-aligned poly (L-lactic acid) (PLLA)/polycaprolactone (PCL) fibers obtained by electrospinning, associated to electrosprayed hydroxyapatite (HA) for tissue engineering applications were developed and their performance was compared in terms of their morphology and biological and mechanical behaviors. The morphological results assessed by scanning electron microscopy showed a mes...
Exposure effects of endotoxin-free titanium-based wear particles to human osteo...
Costa, Bruna C. [UNESP]; Alves, Alexandra C.; Toptan, Fatih; Pinto, Ana M.; Grenho, Liliana; Fernandes, Maria H.; Petrovykh, Dmitri Y.Made available in DSpace on 2019-10-06T15:39:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-07-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Titanium-based materials are widely employed by the biomedical industry in orthopedic and dental implants. However, when placed into the human body, these materials are highly susceptible to degradation processes, such as corrosion, we...
Exposure effects of endotoxin-free titanium-based wear particles to human osteo...
Costa, Bruna C.; Alves, Alexandra Manuela Vieira Cruz Pinto; Toptan, Fatih; Pinto, A. M. P.; Grenho, Liliana; Fernandes, Maria H.; Petrovykh, Dmitri Y.Titanium-based materials are widely employed by the biomedical industry in orthopedic and dental implants. However, when placed into the human body, these materials are highly susceptible to degradation processes, such as corrosion, wear, and tribocorrosion. As a consequence, metallic ions or particles (debris) may be released, and although several studies have been conducted in recent years to better understan...
Engineering a multifunctional 3D-printed PLA-collagen-minocycline-nanoHydroxyap...
Martin, Victor; Ribeiro, Isabel A. C.; Alves, Marta M.; Gonçalves, Lídia; Claudio, Ricardo A.; Grenho, Liliana; Fernandes, Maria H.; Gomes, Pedro3D-printing and additive manufacturing can be powerful techniques to design customized structures and produce synthetic bone grafts with multifunctional effects suitable for bone repair. In our work we aimed the development of novel multifunctionalized 3D printed poly(lactic acid) (PLA) scaffolds with bioinspired surface coatings able to reduce bacterial biofilm formation while favoring human bone marrow-derive...