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Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation...
Lemos, Henrique Paula; Grespan, Renata; Manfredo Vieira, Silvio; Cunha, Thiago Mattar; Verri, Waldiceu A.; Fernandes, Karla S.; Souto, Fabrício OliveiraIL-23/IL-17-induced neutrophil recruitment plays a pivotal role in rheumatoid arthritis (RA). However, the mechanism of the neutrophil recruitment is obscure. Here we report that prostaglandin enhances the IL-23/IL-17-induced neutrophil migration in a murine model of RA by inhibiting IL-12 and IFN γ production. Methylated BSA (mBSA) and IL-23-induced neutrophil migration was inhibited by anti-IL-23 and anti-IL-...
Data: 2020
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Origem: Oasisbr