6 documents found, page 1 of 1
Cardiac Molecular Analysis Reveals Aging-Associated Metabolic Shift in the Left...
Grilo, Luís F.; Zimmerman, Kip D.; Puppala, Sobha; Chan, Jeannie; Huber, Hillary F.; Li, Ge; Jadhav, Avinash Y. L.; Wang, Benlian; Li, CunAge is a prominent risk factor for cardiometabolic disease, often leading to heart structural and functional changes. However, precise molecular mechanisms underlying cardiac remodeling and dysfunction exclusively resulting from physiological aging remain elusive. Previous research demonstrated age-related functional alterations in baboons, analogous to humans. The goal of this study is to identify early cardia...
Maternal heart exhibits metabolic and redox adaptations post-uncomplicated preg...
Tocantins, Carolina; Martins, João D.; Rodrigues, Óscar M; Grilo, Luís F.; Diniz, Mariana S.; Stevanovic-Silva, Jelena; Beleza, Jorge; Coxito, PedroPregnancy may be a challenging period for the maternal systems and has been regarded as a stress test, as imperceptible/mild dysfunctions eventually present may be exacerbated during this period. The cardiovascular system is no exception, and several morphological and functional adaptations accompanying pregnancy have been described. However, long-term pregnancy-induced cardiac molecular alterations remain high...
Monoamine oxidase A-dependent ROS formation modulates human cardiomyocyte diffe...
Di Sante, Moises; Antonucci, Salvatore; Pontarollo, Laura; Cappellaro, Ilaria; Segat, Francesca; Deshwal, Soni; Greotti, Elisa; Grilo, Luís F.During embryonic development, cardiomyocytes undergo differentiation and maturation, processes that are tightly regulated by tissue-specific signaling cascades. Although redox signaling pathways involved in cardiomyogenesis are established, the exact sources responsible for reactive oxygen species (ROS) formation remain elusive. The present study investigates whether ROS produced by the mitochondrial flavoenzym...
Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by ...
Diniz, Mariana S.; Grilo, Luís F.; Tocantins, Carolina; Falcão-Pires, Inês; Pereira, Susana P.Obesity incidence has been increasing at an alarming rate, especially in women of reproductive age. It is estimated that 50% of pregnancies occur in overweight or obese women. It has been described that maternal obesity (MO) predisposes the offspring to an increased risk of developing many chronic diseases in an early stage of life, including obesity, type 2 diabetes, and cardiovascular disease (CVD). CVD is th...
The birth of cardiac disease: Mechanisms linking gestational diabetes mellitus ...
Tocantins, Carolina; Diniz, Mariana S.; Grilo, Luís F.; Pereira, Susana P.Cardiovascular disease (CVD) is the biggest killer worldwide, composing a major economic burden for health care systems. Obesity and diabetes are dual epidemics on the rise and major risk factors predisposing for CVD. Increased obesity- and diabetes-related incidence is now observed among children, adolescents, and young adults. Gestational diabetes mellitus (GDM) is the most common metabolic pregnancy disorder...
A Mitochondrial Approach to Cardiovascular Risk and Disease
Veloso, Caroline D.; Belew, Getachew D.; Ferreira, Luciana L.; Grilo, Luís F.; Jones, John Griffith; Portincasa, Piero; Sardão, Vilma A.Cardiovascular diseases (CVDs) are a leading risk factor for mortality worldwide and the number of CVDs victims is predicted to rise through 2030. While several external parameters (genetic, behavioral, environmental and physiological) contribute to cardiovascular morbidity and mortality; intrinsic metabolic and functional determinants such as insulin resistance, hyperglycemia, inflammation, high blood pressure...