28 documents found, page 1 of 3
Exposure to tricyclic antidepressant nortriptyline affects early-life stages of...
Oliveira, Ana C.; Fascineli, Maria Luiza; Andrade, Thayres S.; Moura, Diego Sousa; Domingues, Inês; Camargo, Níchollas S.; Oliveira, RhaulPsychiatric drugs are among the leading medications prescribed for humans, with their presence in aquatic environments raising concerns relating to potentially harmful effects on non-target organisms. Nortriptyline (NTP) is a selective serotonin-norepinephrine reuptake inhibitor antidepressant, widely used in clinics and found in environmental water matrices. In this study, we evaluated the toxic effects of NTP...
Evaluation of the embryotoxicity in zebrafish (Danio rerio) of the flocculant a...
Moura, Diego Sousa; Mota, Rafael Oliveira Duarte da; Gonçalves Júnior, José Francisco; Vasconcelos, Newton Flávio de; Reis, Marco AurélioObjetivo: O carreamento decorrente das atividades de mineração atinge corpos d'água, causando contaminação da água e acidificação por metais tóxicos. Como conseqüência, a depleção de oxigênio ocorre, com o desaparecimento de certos organismos bênticos, perdas na biomassa do fitoplâncton e do zooplâncton, e mortalidade de peixes. Remediação da água contaminada da mineração envolve o uso de floculantes baseados e...
Toxicological findings about an anticancer fraction with casearins described by...
Pinheiro Fetreira, Paulo Michel; Santos, Denise Barbosa; Silva, Jurandy do Nascimento; Goudinho, Amanda Freitas; Silva Ramos, Carla LorenaMade available in DSpace on 2019-10-04T12:15:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-09-15; Fundacao de Amparo a Pesquisa do Estado do Piaui [FAPEPI]; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Ethnopharmacological relevance: Extracts, essential oils and molecules from Casearia sylvestris have popularly shown pharmacological actions against chronic diseases, as anxie...
Comet and cytogenetic tests as tools for evaluating genomic instability in seed...
Dantas, Alisson F.; Lopes, Renata M.; Fascineli, Maria Luiza; José, Solange C. B. R.; Pádua, Juliano G.; Gimenes, Marcos A.; Grisolia, Cesar KoppeThis study aimed to assess the feasibility of comet and cytogenetic tests as tools for evaluating genomic instability in seeds of Oryza sativa L. (rice) and Phaseolus vulgaris (beans) L. from gene banks. Rice and beans were exposed to methyl methanesulfonate (MMS) as a reference DNA damaging agent. Seeds of two accessions of rice and beans were obtained from Embrapa Rice and Beans - Brazil. Seed groups were imb...
The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against agi...
Roll, Mariana Matos; Vilela, Ana Luísa Miranda; Longo, João Paulo Figueiró; Agostini-Costa, Tânia da Silveira; Grisolia, Cesar KoppeContinued exposure to reactive oxygen species and inflammation are the rationale behind aging theories and associated diseases. Scientific evidence corroborates the ethnomedicinal use of the oil of pequi (Caryocar brasiliense Camb.), a typical Brazilian Cerrado fruit, against oxidative damage to biomolecules and inflammation. We aimed to investigate in vivo the antioxidant and anti-inflammatory effects of pequi...
Toxicological study of the degradation products of antineoplastic agent etoposi...
de Sousa Filho, Idio Alves; Lobo, Tatiane Martins; Grisolia, Cesar Koppe; Weber, Ingrid Távora; Osugi, Marly Eiko [UNESP]Made available in DSpace on 2018-12-11T17:18:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-02-20; Etoposide is an antineoplastic agent used for treating lung cancer, testicular cancer, breast cancer, pediatric cancers, and lymphomas. It is a pollutant due to its mutagenic and carcinogenic potential. Disposal of waste from this drug is still insufficiently safe, and there is no appropriate waste trea...
Electrochemical remediation of amoxicillin: detoxification and reduction of ant...
Brito, Lara Barroso; Garcia, Luane Ferreira; Caetano, Marcos Pereira; Lobón, Germán Sanz; Teles de Oliveira, Mayk; de Oliveira, RhaulMade available in DSpace on 2018-12-11T16:54:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-08-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Amoxicillin (AMX) is one of the most commonly prescribed antibiotics around the world to treat and prevent several diseases in both human and veterinary medicine. Incomplete removal of AMX during wastewater treatment contributes to it...
. Acesso em: 24 out. 2017. doi: http://dx.doi.org/10.1590/S1415-47572010005000022." title="8. Dietary carotenoid-rich oil supplementation improves exercise-induced anisocytosis in runners : influences of haptoglobin, MnSOD (Val9Ala), CAT (21A/T) and GPX1 (Pro198Leu) gene polymorphisms in dilutional pseudoanemia ("sports anemia")">Dietary carotenoid-rich oil supplementation improves exercise-induced anisocyto...
Vilela, Ana Luísa Miranda; Akimoto, Arthur Kenji; Alves, Penha Cristina Zaidan; Pereira, Luiz Carlos da Silva; Guimarães, Maria de Nazaré KlautauPhysical training induces beneficial adaptation, whereas exhaustive exercises increase reactive oxygen-species generation, thereby causing oxidative damage in plasma and erythrocytes, fractions susceptible to lipid peroxidation. Pequi (Caryocar brasiliense Camb.) is a Brazilian Cerrado fruit containing a carotenoid-rich oil. The aim was to investigate the effects of pequi-oil on exercise-induced oxidative damag...
β-globin haplotypes in normal and hemoglobinopathic individuals from Reconcavo ...
Silva, Wellington dos Santos; Guimarães, Maria de Nazaré Klautau; Grisolia, Cesar KoppeFive restriction site polymorphisms in the β-globin gene cluster (HincII-5'ε, HindIII-Gγ, HindIII-ªγ, HincII-'ψβ1 and HincII-3''ψβ1) were analyzed in three populations (n = 114) from Reconcavo Baiano, State of Bahia, Brazil. The groups included two urban populations from the towns of Cachoeira and Maragojipe and one rural Afro-descendant population, known as the "quilombo community", from Cachoeira municipality...
Distribution of glutathione S-transferase GSTM1 and GSTT1 null phenotypes in Br...
Guimarães, Maria de Nazaré Klautau; Hiragi, Cássia de Oliveira; D'Ascenção, Renata Ferreira; Oliveira, Silviene Fabiana de; Grisolia, Cesar KoppeThe distribution of glutathione S-transferase (GST) GSTM1 and GSTT1 null phenotype frequencies in two Brazilian Amerindian tribes, the Munduruku tribe from Missão Cururu village (79 individuals) and the Kayabi tribe (41 individuals), was analyzed by polymerase chain reaction (PCR) amplification. The GST null phenotype frequencies for the Munduruku sample were 0% for GSTM1 and 27% for GSTT1 while for the Kayabi ...