10 documents found, page 1 of 1
How a GPT-aided survey reveals a medical student's misunderstanding of the term...
Pereira, Sara M.; Grobusch, Martin P.; Hanscheid, ThomasIn infectious diseases and microbiology, "resistance" implies a lack of drug effectiveness, necessitating a change in therapy. The term "artemisinin resistance" was unfortunately used to describe a longer time for parasites to be cleared from the patient's bloodstream. However, the use of this scientifically flawed term may be mistakenly interpreted to mean that artemisinin-based therapies are ineffective, pote...
Epidemiological and clinical characteristics of patients with monkeypox in the ...
Angelo, Kristina M.; Smith, Teresa; Camprubí-Ferrer, Daniel; Balerdi-Sarasola, Leire; Díaz Menéndez, Marta; Servera-Negre, Guillermo; Barkati, SaphaBackground: The early epidemiology of the 2022 monkeypox epidemic in non-endemic countries differs substantially from the epidemiology previously reported from endemic countries. We aimed to describe the epidemiological and clinical characteristics among individuals with confirmed cases of monkeypox infection. Methods: We descriptively analysed data for patients with confirmed monkeypox who were included in the...
Discontinuing atovaquone/proguanil prophylaxis ad-hoc post-exposure and during-...
Schnyder, Jenny L.; de Jong, Hanna K.; Schlagenhauf, Patricia; Borrmann, Steffen; Hanscheid, Thomas; Grobusch, Martin P.Background: Atovaquone/proguanil (AP) is a highly effective malaria chemoprophylaxis combination. According to current guidelines, AP is taken once daily during, and continued for seven days post exposure. A systematic review by Savelkoel et al. summarised data up to 2017 on abbreviated AP regimens, and concluded that discontinuing AP upon return may be effective, although the available data was insufficient to...
Antimalarial treatment in infants
Kalkman, Laura C.; Hanscheid, Thomas; Krishna, Sanjeev; Kremsner, Peter G.; Grobusch, Martin P.Introduction: Malaria in infants is common in high-transmission settings, especially in infants >6 months. Infants undergo physiological changes impacting pharmacokinetics and pharmacodynamics of anti-malarial drugs and, consequently, the safety and efficacy of malaria treatment. Yet, treatment guidelines and evidence on pharmacological interventions for malaria often fail to address this vulnerable age group. ...
Fluid therapy for severe malaria
Kalkman, Laura C.; Hanscheid, Thomas; Krishna, Sanjeev; Grobusch, Martin P.Fluid therapy is an important supportive measure for patients with severe malaria. Patients with severe malaria usually have normal cardiac index, vascular resistance, and blood pressure and a small degree of hypovolaemia due to dehydration. Cell hypoxia, reduced kidney function, and acidosis result from microcirculatory compromise and malarial anaemia, which reduce tissue oxygenation, not hypovolaemia. Hence, ...
Point-of-care ultrasound to assess volume status and pulmonary oedema in malari...
Pugliese, Christina M.; Adegbite, Bayode R.; Edoa, Jean R.; Mombo-Ngoma, Ghyslain; Obone-Atome, Fridia A.; Heuvelings, Charlotte C.; Bélard, SabinePurpose: Fluid management is challenging in malaria patients given the risks associated with intravascular fluid depletion and iatrogenic fluid overload leading to pulmonary oedema. Given the limitations of the physical examination in guiding fluid therapy, we evaluated point-of-care ultrasound (POCUS) of the inferior vena cava (IVC) and lungs as a novel tool to assess volume status and detect early oedema in m...
Coronavirus 2019-nCoV: is the genie already out of the bottle?
Hanscheid, Thomas; Valadas, Emília; Grobusch, Martin P.Once again, a virus has jumped the species barrier. Coronavirus 2019-nCoV emerged apparently in a wet market in China, and after a few weeks the number of cases already exceeds those of SARS in 2002/03 (Fig. 1) in terms of both morbidity and mortality. Excellent publications have addressed many aspects of a possible novel endemic/pandemic zoonosis, often with a focus on MERS-CoV (2–4), includingprevention, drug...
Can dengue virus be sexually transmitted?
Grobusch, Martin P.; van der Fluit, Karin S.; Stijnis, Cornelis; De Pijper, Cornelis A.; Hanscheid, Thomas; Gautret, Philippe; Schlagenhauf, PatriciaIt has been well documented that Zika virus (ZIKV) can be sexually transmitted. Dengue virus (DENV) shows many similarities with ZIKV; both belong to the genus Flavivirus and share the same main vector route of transmission. Moreover, they share overall architectural features on a molecular level, with a highly similar structure and distinctive insertions, deletions and mutations of their respective E proteins,...
Ebola 2018 - Implications for travel health advice and relevance for travel med...
Grobusch, Martin P.; Schaumburg, Frieder; Weitzel, Thomas; Rothe, Camilla; Hanscheid, Thomas; Goorhuis, AbrahamSince 1976, in more than 40 recorded outbreaks to date, Ebola virus disease (EVD) has dramatically affected the human population across the Central African region and adjacent areas. The large West African outbreak (2013–2015) was a game changer in many aspects, not only with regard to geographical location and the number of patients and deaths, but also in terms of the international community's response it fin...
How useful is PCR in the diagnosis of malaria?
Hanscheid, Thomas; Grobusch, Martin P.Polymerase chain reaction (PCR) assays are the most sensitive and specific method to detect malaria parasites, and have acknowledged value in research settings. However, the time lag between sample collection, transportation and processing, and dissemination of results back to the physician limits the usefulness of PCR in routine clinical practice. Furthermore, in most areas with malaria transmission, factors s...