26 documents found, page 1 of 3
The role of gastrostomy and noninvasive ventilation in primary lateral sclerosis
Oliveira Santos, Miguel; Domingues, Sara; Simão, Sara; Gromicho, Marta; Alves, Inês; Carvalho, MamedeIntroduction/aims: Literature on the role of gastrostomy and noninvasive ventilation (NIV) in primary lateral sclerosis (PLS) is limited. We aim to investigate whether PLS patients develop dysphagia requiring feeding tubes or respiratory failure necessitating NIV. Methods: We conducted a retrospective study of PLS patients with a definite diagnosis followed at our center (1994-2024). Patients with marked dyspha...
Predicting clinical events characterizing the progression of amyotrophic latera...
Guazzo, Alessandro; Atzeni, Michele; Idi, Elena; Trescato, Isotta; Tavazzi, Erica; Longato, Enrico; Manera, Umberto; Chió, Adriano; Gromicho, MartaBackground: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that results in death within a short time span (3-5 years). One of the major challenges in treating ALS is its highly heterogeneous disease progression and the lack of effective prognostic tools to forecast it. The main aim of this study was, then, to test the feasibility of predicting relevant clinical outcomes that char...
Artificial intelligence and statistical methods for stratification and predicti...
Tavazzi, Erica; Longato, Enrico; Vettoretti, Martina; Aidos, Helena; Trescato, Isotta; Roversi, Chiara; Martins, Andreia S.; Castanho, Eduardo N.Background: Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder characterised by the progressive loss of motor neurons in the brain and spinal cord. The fact that ALS's disease course is highly heterogeneous, and its determinants not fully known, combined with ALS's relatively low prevalence, renders the successful application of artificial intelligence (AI) techniques particularly arduous...
Clinical characteristics in amyotrophic lateral sclerosis with Sub-Saharan Afri...
Oliveira Santos, Miguel; Gromicho, Marta; Pinto, Susana; Pronto Laborinho, Ana Catarina; Carvalho, MamedeAmyotrophic lateral sclerosis (ALS) is a rapidly progressive condition characterized by upper and lower motor neuron loss. Over the last decades, epidemiological and clinical data from European, North America and high-incoming Asia-Pacific countries has been extensively collected and analyzed, improving the knowledge regarding ALS. However, ALS had not been reported in Africans until 1955. Even today, data from...
Respiratory phenotypes in amyotrophic lateral sclerosis as determined by respir...
Pinto, Susana; Oliveira Santos, Miguel; Gromicho, Marta; Swash, Michael; Carvalho, MamedeBackground and purpose: Respiratory insufficiency and its complications are the main cause of death in amyotrophic lateral sclerosis (ALS). Respiratory symptoms are scored in questions Q10 (dyspnoea) and Q11 (orthopnoea) of the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R). The association of respiratory test alterations with respiratory symptoms is unclear. Methods: Patients with ALS...
Association of the practice of contact sports with the development of amyotroph...
Henriques, Ana; Gromicho, Marta; Grosskreutz, Julian; Kuzma-Kozakiewicz, Magdalena; Petri, Susanne; Uysal, Hilmi; Pinto, Susana; Antunes, MariliaObjectives: High-intensity physical activity and sports prone to repetitive injuries of the cervical spine and head (when associated with vigorous practice) have been suggested as possible risk factors for amyotrophic lateral sclerosis (ALS). Our objective was to evaluate the relationship between the practice of contact sports (boxing, hockey, football, rugby) and ALS. Methods: The study included 2247 individua...
Respiratory function tests in amyotrophic lateral sclerosis: the role of maxima...
Carvalho, Mamede; Fernandes, Sofia Rita; Pereira, Mariana; Gromicho, Marta; Oliveira Santos, Miguel; Alves, Inês; Pinto, Susana; Swash, MichaelBackground: Pulmonary function tests are routinely used to measure progression in ALS. This study aimed to assess the change of various respiratory tests, in particular maximal voluntary ventilation (MVV), which evaluates respiratory endurance. Methods: A group of 51 patients were assessed 3 times (T1, T2, T3, separated by 5.4 months), including slow (SVC) and forced vital capacity (FVC), forced expiratory volu...
Dynamic Bayesian networks for stratification of disease progression in amyotrop...
Gromicho, Marta; Leão, Tiago; Oliveira Santos, Miguel; Pinto, Susana; Carvalho, Alexandra M.; Madeira, Sara C.; Carvalho, MamedeBackground and purpose Progression rate is quite variable in amyotrophic lateral sclerosis (ALS); thus, tools for profiling disease progression are essential for timely interventions. The objective was to apply dynamic Bayesian networks (DBNs) to establish the influence of clinical and demographic variables on disease progression rate. Methods In all, 664 ALS patients from our database were included stratified ...
Learning prognostic models using a mixture of biclustering and triclustering: p...
Soares, Diogo F.; Henriques, Rui; Gromicho, Marta; Carvalho, Mamede; Madeira, Sara C.Longitudinal cohort studies to study disease progression generally combine temporal features produced under periodic assessments (clinical follow-up) with static features associated with single-time assessments, genetic, psychophysiological, and demographic profiles. Subspace clustering, including biclustering and triclustering stances, enables the discovery of local and discriminative patterns from such multid...
Respiratory onset in amyotrophic lateral sclerosis: clinical features and sprea...
Pinto, Susana; Gromicho, Marta; Oliveira Santos, Miguel; Swash, Michael; Carvalho, MamedeObjective To describe the clinical features and progression of patients with respiratory onset amyotrophic lateral sclerosis (ALS). Methods: We analyzed the clinical features, including respiratory tests, functional score, noninvasive ventilation (NIV) time and survival of ALS patients with respiratory-onset in our database consisting of 1688 patients. In a subset of 625 ALS patients we analyzed the spreading p...