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Managing intrathecal administration of nusinersen in adolescents and adults wit...
Mendonça,Rodrigo de Holanda; Fernandes,Hermann dos Santos; Pinto,Rafael Barbéro Schimmelpfeng; Matsui Júnior,Ciro; Polido,Graziela JorgeABSTRACT Background: Spinal muscular atrophy (SMA) is a neurodegenerative disease of lower motor neurons associated with frequent occurrence of spinal deformity. Nusinersen is an antisense oligonucleotide that increases SMN protein level and is administrated by frequent intrathecal lumbar injections. Thus, spinal deformities and previous spinal surgery are important challenges for drug delivery in SMA. Objectiv...
Date: 2021
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Origin: Oasisbr