7 documents found, page 1 of 1
Safety and tolerability of a single dose T0001 in Chinese healthy adult volunte...
Zhang, Tan; Zhang, Minjie; Zu, Li’an; Wang, Qian; Wang, Qi; Wang, Wei; Wang, Yitong; Zang, Yannan; Xie, Zhenwei; Chen, Shi; Wang, Mei; Zheng, QingshanT0001 is the first mutant of etanercept with a higher affinity to tumor necrosis factor α (TNF-α) than etanercept. In order to investigate the safety and tolerability of T0001, a study was carried out in healthy Chinese subjects. A first-in-human, dose escalation study was conducted in healthy Chinese subjects. Fifty-six subjects were divided into six dose cohorts (10 mg, 20 mg, 35 mg, 50 mg, 65 mg and 75 mg) t...
Correlation between Myocardial Velocity Measured using Tissue Doppler Imaging i...
Yang, Dong-Mei; Yu, Fei; Chen, Kang-Yu; Su, Hao; Wang, Qi; Liu, Zhi-Quan; Hu, Kai; Xu, Jian; Yan, JiOBJECTIVES: This study investigated whether tissue Doppler imaging parameters, especially the peak systolic velocity of the left ventricular lead-implanted segment (Ss), affect cardiac resynchronization therapy response. METHODS: In this case-control study, 110 enrolled patients were divided into cases (responder group, n=65) and controls (nonresponder group, n=45) based on whether their left ventricular end-sy...
Abnormal diastolic function underlies the different beneficial effects of cardi...
Wang, Qi; Chen, Kang-Yu; Yu, Fei; Su, Hao; An, Chun-Sheng; Hu, Yang; Yang, Dong-Mei; Xu, Jian; Yan, JiOBJECTIVES: To investigate the association between diastolic function and the different beneficial effects of cardiac resynchronization therapy in patients with heart failure due to different causes. METHODS: The 104 enrolled patients were divided into an ischemic cardiomyopathy group (n=27) and a non-ischemic cardiomyopathy group (n=77) according to the cause of heart failure. Before implantation, left ventric...
Comparison of short-segment monoaxial and polyaxial pedicle screw fixation comb...
Wang, Hongwei; Zhao, Yiwen; Mo, Zhongjun; Han, Jianda; Chen, Yu; Yu, Hailong; Wang, Qi; Liu, Jun; Li, Changqing; Zhou, Yue; Xiang, LiangbiOBJECTIVES: No studies have compared monoaxial and polyaxial pedicle screws with regard to the von Mises stress of the instrumentation, intradiscal pressures of the adjacent segment and adjacent segment degeneration. METHODS: Short-segment monoaxial/polyaxial pedicle screw fixation techniques were compared using finite element methods, and the redistributed T11-L1 segment range of motion, largest maximal von Mi...
Carbothermal synthesis of micro-scale spherical AlN granules with CaF2 additive
Wang, Qi; Ge, Yiyao; Cui, Wei; Chen, Kexin; Ferreira, José M.F.; Xie, ZhipengIn this work, we purposefully reported a simple yet efficient carbothermal synthesis strategy to prepare micro scale spherical AlN granules just by using CaF2 as promoting additive. The effects of synthesis parameters, such as CaF2 content, N2 gas pressure, reaction temperature, upon the nitridation rate, surface morphology and particle size were comprehensively investigated. It was established that elevated N2...
Carbothermal synthesis of micro-scale spherical AlN granules with CaF2 additive
Wang, Qi; Ge, Yiyao; Cui, Wei; Chen, Kexin; Ferreira, Jose M. F.; Xie, ZhipengIn this work, we purposefully reported a simple yet efficient carbothermal synthesis strategy to prepare micro-scale spherical AlN granules just by using CaF2 as promoting additive. The effects of synthesis parameters, such as CaF2 content, N-2 gas pressure, reaction temperature, upon the nitridation rate, surface morphology and particle size were comprehensively investigated. It was established that elevated N...
Hydrolysis Control of AlN Powders for the Aqueous Processing of Spherical AlN G...
Wang, Qi; Olhero, Susana M.; Ferreira, Jose M. F.; Cui, Wei; Chen, Kexin; Xie, ZhipengSpherical granules of aluminum nitride (AlN) with an average particle size of about 50m were produced from aqueous suspensions using an AlN powder surface treated against hydrolysis with aluminum dihydrogenphosphate [Al(H2PO4)3]. Two different amounts of Al(H2PO4)3 were tested and the effects of surface treatment and aging time were evaluated by various techniques (XRD, TG-DTA, zeta potential and pH measurement...