17 documents found, page 1 of 2
Comparison of the serum whole molecular composition with the serum metabolome t...
Correia, Inês; Henrique Fonseca, Tiago Alexandre; Pataco, Jéssica; Oliveira, Mafalda; Caldeira, Viviana; Domingues, N.; Von Rekowski, CristianaOmics Sciences serve as an essential tool to advance precision medicine. Since conventional omics sciences rely on laborious, complex and time-consuming analytical processes, this study evaluated whether the serum molecular fingerprint, captured by FTIR spectroscopy, could predict mortality risk in critically ill patients. Both the whole serum and the serum metabolome (i.e., serum after removal of macromolecule...
Anaplasma marginale and Theileria annulata in questing ticks from Portugal
Antunes, S.; Ferrolho, J.; Domingues, N.; Santos, A.S.; Santos-Silva, M.M.; Domingos, A.Ticks are ubiquitous arthropods and vectors of several pathogenic agents in animals and humans. Monitoring questing ticks is of great importance to ascertain the occurrence of pathogens and the potential vector species, offering an insight into the risk of disease transmission in a given area. In this study 428 host-seeking ticks, belonging to nine species of Ixodidae and collected from 17 of the 23 Portuguese ...
Therapeutic properties of VO(dmpp)2 as assessed by in vitro and in vivo studies...
Domingues, N.; Pelletier, J.; Ostenson, C.-G.; Castro, M. M. C. A.The bis(1,2-dimethyl-3-hydroxy-4-pyridinonato)oxidovanadium(IV), VO(dmpp)2, has shown anti-diabetic effects by in vitro studies in Wistar (W) rat adipocytes and in vivo in obese Zucker rats. The aim of this work is to confirm the therapeutic properties of VO(dmpp)2 in non-obese type 2 diabetic Goto-Kakizaki (GK) rats. An in vivo study was carried out, treating W and GK rats during 21 days with a daily dose of V...
Photoinhibition in benthic diatom assemblages under light stress
Cartaxana, P.; Domingues, N.; Cruz, S.; Jesus, B.; Laviale, M.; Serôdio, J.; Da Silva, J. MarquesMicrophytobenthos are frequently subjected to light intensities higher than those required to saturate photosynthesis, which consequently can cause photoinhibition. Photosystem II (PSII) protein D1 (the main target of photoinhibition) and xanthophyll cycle pigments were quantified in epipelic benthic diatom assemblages under high irradiance, in the presence of inhibitors and promoters of photoprotection mechani...
A quantitative approach to assess the mixing ability of single-screw extruders ...
Domingues, N.; Gaspar-Cunha, A.; Covas, J. A.Models to predict the evolution of the morphology of immiscible liquid-liquid systems and of solid agglomerates dispersion in single-screw extruders were adapted to compute global distributive and dispersive mixing indices. Using these indices, the direct assessment of the mixing ability of a given screw or a comparison of distinct screws becomes readily available. In the case of liquid-liquid systems, the degr...
Mixing in single screw extrusion: modelling and optimization
Domingues, N.Given the importance of mixing in polymer processing, the aim of this work is to implement a mathematical model for quantifying the mixing behaviour in single screw extruders. The model developed considers the incorporation of solid or liquid additives into a polymeric matrix. For this purpose, the existing numerical routines capable of describing the flow in the melting and melt conveying zones of the extruder...
Dynamics of filler size and spatial distribution in a plasticating single screw...
Domingues, N.; Gaspar-Cunha, A.; Covas, J. A.; Camesasca, M.; Kawasse, F. M.; Manas-Zloczower, I.A model of agglomerate break-up, incorporating both rupture and erosion, is employed to predict the dynamics of filler size distribution in a plasticating single screw extruder. Filler spatial distribution along the extruder length was also ascertained and direct comparison of experimental and computational data proved to be satisfactory. The method was also used to investigate the effect of material properties...
Modeling of agglomerate dispersion in single screw extruders
Domingues, N.; Camesasca, M.; Kaufman, M.; Manas-Zloczower, I.; Gaspar-Cunha, A.; Covas, J. A.A model for solid agglomerate dispersion in single screw extruders is proposed. The model combines numerical simulations of flow patterns in the metering section of a single screw extruder with a Monte Carlo method of clusters rupture and erosion mediated by a local fragmentation number. Particle size distributions and Shannon entropy are used for mixing characterization. The model is quite general and can be a...
Estimation of the morphology development of immiscible liquid-liquid systems du...
Gaspar-Cunha, A.; Covas, J. A.; Domingues, N.A mathematical model to predict the evolution of the morphology of immiscible liquid-liquid systems in single screw extruders has been developed. The model computes the dimensions of the dispersed phase in the polymeric matrix, taking into account the stretching, break-up, and coalescence phenomena. The corresponding routine was inserted in a process modeling software, describing the flow in a single screw extr...
Global mixing indices for single screw extrusion
Domingues, N.; Gaspar-Cunha, A.; Covas, J. A.The present work presents numerical simulations of dispersive and distributive mixing of a two phase system being processed in a single screw extruder under various conditions. Models were developed to quantify the degree of mixing of liquid-liquid and solids-liquid systems, for a given set of material properties, operating conditions and extruder geometry.