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Strong correlation between the rates of intrinsically antibiotic-resistant spec...

Jarlier, Vincent; Diaz Högberg, Liselotte; Heuer, Ole E.; Campos, José; Eckmanns, Tim; Giske, Christian G.; Grundmann, Hajo; Johnson, Alan P

Background: Antibiotic resistance, either intrinsic or acquired, is a major obstacle for treating bacterial infections.AimOur objective was to compare the country-specific species distribution of the four Gram-negative species Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter species and the proportions of selected acquired resistance traits within these species.MethodWe used dat...


Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by n...

David, Sophia; Reuter, Sandra; Harris, Simon R.; Glasner, Corinna; Feltwell, Theresa; Argimon, Silvia; Abudahab, Khalil; Goater, Richard; Giani, Tommaso

Public health interventions to control the current epidemic of carbapenem-resistant Klebsiella pneumoniae rely on a comprehensive understanding of its emergence and spread over a wide range of geographical scales. We analysed the genome sequences and epidemiological data of >1,700 K. pneumoniae samples isolated from patients in 244 hospitals in 32 countries during the European Survey of Carbapenemase-Producing ...


Occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia col...

Grundmann, Hajo; Glasner, Corinna; Albiger, Barbara; Aanensen, David M.; Tomlinson, Chris T.; Andrasević, Arjana Tambić; Cantón, Rafael; Carmeli, Yehuda

BACKGROUND: Gaps in the diagnostic capacity and heterogeneity of national surveillance and reporting standards in Europe make it difficult to contain carbapenemase-producing Enterobacteriaceae. We report the development of a consistent sampling framework and the results of the first structured survey on the occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in European hospitals. M...


Carbapenemase-producing Enterobacteriaceaein Europe: assessment by national exp...

Albiger, Barbara; Glasner, Corinna; Struelens, Marc J.; Grundmann, Hajo; Monnet, Dominique L.

In 2012, the European Centre for Disease Prevention and Control (ECDC) launched the 'European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE)' project to gain insights into the occurrence and epidemiology of carbapenemase-producing Enterobacteriaceae (CPE), to increase the awareness of the spread of CPE, and to build and enhance the laboratory capacity for diagnosis and surveillance of CPE in Eur...


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